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首页> 外文期刊>Journal of Oral Microbiology >Polymorphisms in the interleukin-10 gene and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases
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Polymorphisms in the interleukin-10 gene and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases

机译：动脉粥样硬化和主动脉瘤性血管疾病患者白细胞介素10基因多态性与慢性牙周炎

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Background Chronic periodontitis (CP), atherosclerotic and aortic aneurysmal vascular diseases (VD) are chronic inflammatory conditions with multifactorial etiologies, including involvement of predisposing genetic factors. In a previous study, polymorphisms in the gene for the anti-inflammatory interleukin-1 receptor antagonist were associated with CP in patients with VD. Objective This study investigates whether polymorphisms in the gene for the anti-inflammatory interleukin-10 (IL10) could be related to CP in the same manner. Methods Seventy-two patients with VD of whom 35 had CP were genotyped for single nucleotide polymorphisms (SNPs) in the IL10 ?592 (rs1800872), ?819 (rs1800871), and ?1,082 (rs1800896) gene by Taqman rtPCR method and by DNA sequencing. Results The C alleles and C/C genotypes of IL10 ?592 and IL10 ?819 frequencies were significantly higher, while the frequencies of the IL10 ?592 (C/A) and IL10 ?819 (C/T) heterozygote genotypes were significantly lower in the VD group with CP compared to those without CP. The IL10 haplotype ATA frequency (?1,082, ?819, ?592) showed a trend to a significant difference between the two groups indicating protection against CP. Conclusions Taken together, our findings suggest an independent association of genetic polymorphisms in the IL-10 gene locus with CP in patients with VD. Development of CP and the implications on vascular disease emphasize the importance of early detection and adequate treatment of periodontitis among these patients.
机译：背景慢性牙周炎（CP），动脉粥样硬化和主动脉瘤血管疾病（VD）是具有多种病因的慢性炎症，包括易感遗传因素。在先前的研究中，抗炎性白介素-1受体拮抗剂基因的多态性与VD患者的CP有关。目的研究抗炎性白介素10（IL10）基因的多态性是否可能以同样的方式与CP相关。方法采用Taqman rtPCR方法和DNA方法对72例VD患者（其中35例患有CP）的IL10？592（rs1800872）、? 819（rs1800871）和？1,082（rs1800896）基因中的单核苷酸多态性（SNP）进行基因分型。排序。结果IL10〜592和IL10〜819频率的C等位基因和C / C基因型显着较高，IL10〜592（C / A）和IL10〜819（C / T）杂合子基因型的频率显着较低。有CP的VD组与没有CP的VD组相比。 IL10单倍型ATA频率（？1,082，？819，？592）显示出两组之间显着差异的趋势，表明对CP具有保护作用。结论综上所述，我们的发现表明VD患者IL-10基因位点的遗传多态性与CP有独立的联系。 CP的发展及其对血管疾病的影响强调了这些患者中牙周炎的早期发现和适当治疗的重要性。

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