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首页> 外文期刊>Journal of Oral Microbiology >The hidden ‘mycobacteriome’ of the human healthy oral cavity and upper respiratory tract
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The hidden ‘mycobacteriome’ of the human healthy oral cavity and upper respiratory tract

机译：人类健康的口腔和上呼吸道的隐藏“分枝杆菌”

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The incidence of opportunistic non-tuberculous mycobacteria (NTM) infections has increased considerably in the past decades causing an array of infections, including respiratory and soft-tissue infections. NTM are ubiquitous and can be found in numerous environments, including households and water plants. However, NTM have not been reported to be associated with the healthy human oral microbiome. Since the oral cavity and upper respiratory track are the main ports of entry of microorganisms into the human body, elucidating NTM diversity and prevalence will assist in the assessment of the potential risks of infection elicited by these opportunistic pathogens. Here, we report the identification of a ‘non-tuberculous mycobacteriome’ in healthy individuals. We employed a modified DNA extraction procedure in conjunction with mycobacterial-specific primers to screen niches in the oral cavity (buccal mucosa and dental plaque) and upper respiratory tract (nostrils and oropharynx) of 10 healthy subjects. A total o...
机译：在过去的几十年中，机会性非结核分枝杆菌（NTM）感染的发生率显着增加，引起一系列感染，包括呼吸道和软组织感染。 NTM无处不在，可以在许多环境中找到，包括家庭和自来水厂。然而，尚未报道NTM与健康的人类口腔微生物组有关。由于口腔和上呼吸道是微生物进入人体的主要途径，因此阐明NTM的多样性和患病率将有助于评估这些机会病原体引起的潜在感染风险。在这里，我们报告了在健康个体中鉴定出的“非结核分枝杆菌”。我们采用了改良的DNA提取程序，结合分枝杆菌特异性引物来筛选10名健康受试者的口腔（颊黏膜和牙菌斑）和上呼吸道（鼻孔和口咽）中的壁ni。总共...

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