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首页> 外文期刊>Journal of Neurology Research >Serum Uric Acid Levels in Acute Ischemic Stroke: A Study of 100 Patients
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Serum Uric Acid Levels in Acute Ischemic Stroke: A Study of 100 Patients

机译：急性缺血性卒中的血清尿酸水平：100例患者的研究

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Background: It is unclear whether Serum Uric Acid (SUA) promotes or protects against the cerebrovascular disease. Present study was done to estimate uric acid levels in patients of acute ischemic stroke.?Methods: 100 cases of acute ischemic stroke were studied along with 100 controls. Risk factors for stroke were noted such as hypertension, diabetes mellitus, metabolic syndrome, smoking, and obesity. Serum uric acid levels were measured in cases and controls. Modified National Institute of Health (NIH) stroke scale score was calculated at admission and before discharge. Statistical analysis was performed with of SPSS 13.0 software.?Results: Out of 100 patients, 63 were males and 37 were females. Mean SUA level in cases was 6.48 ± 1.92 mg/dl whereas it was 5.09 ± 1.07 mg/dl for controls. SUA values were higher among males than females, but this difference was not statistically significant (P = 0.085). The mean SUA in hypertensive subjects (6.42 ± 1.85 mg/dl) was higher than that in normotensive subjects (5.49 ± 1.55 mg/dl). There was a statistically significant difference between SUA levels in diabetic (6.85 ± 1.86 mg/dl, Range 3.1 - 12 mg/dl) and non-diabetic patients (5.56 ± 1.58 mg/dl, Range 2.1 - 11 mg/dl)) (P = 0.00). Mean SUA in overweight patients was 6.48 ± 1.65 mg/dl (Range 2.1 - 9.9 mg/dl) whereas it was 5.55 ± 1.65 (Range 2.1 - 12 mg/dl) in patients who had a normal weight. The mean SUA in patients with metabolic syndrome was 6.82 ± 1.62 mg/dl (Range 2.1 - 10 mg/dl) and 5.45 ± 1.59 mg/dl (Range 2.1 - 12 mg/dl) for the subjects without metabolic syndrome. SUA levels were significantly higher among smokers compared to non smokers (6.36 ± 1.78 vs. 5.69 ± 1.67, P = 0.05). There was a significant positive correlation between SUA and NIH stroke scale score (P?less than?0.05). SUA levels were significantly higher in the patients who succumbed as compared to those who were discharged from the hospital (P = 0.00).?Conclusions: SUA can be used as a marker for increased risk of stroke. Furthermore, SUA can also be used for risk stratification after stroke.?doi:10.4021/jnr71w
机译：背景：目前尚不清楚血清尿酸（SUA）是否能促进或预防脑血管疾病。方法：对100例急性缺血性脑卒中患者和100例对照者进行研究。指出中风的危险因素，例如高血压，糖尿病，代谢综合征，吸烟和肥胖。在病例和对照组中测量血清尿酸水平。在入院时和出院前计算改良的美国国立卫生研究院（NIH）中风量表分数。结果：100例患者中，男63例，女37例。病例中的平均SUA水平为6.48±1.92 mg / dl，而对照组为5.09±1.07 mg / dl。男性的SUA值高于女性，但差异无统计学意义（P = 0.085）。高血压受试者的平均SUA（6.42±1.85 mg / dl）高于血压正常受试者的（5.49±1.55 mg / dl）。糖尿病（6.85±1.86 mg / dl，范围3.1-12 mg / dl）和非糖尿病患者（SUF）的SUA水平在统计学上有显着差异（5.56±1.58 mg / dl，范围2.1-11 mg / dl））（ P = 0.00）。超重患者的平均SUA为6.48±1.65 mg / dl（范围2.1-9.9 mg / dl），而体重正常的患者的SUA为5.55±1.65（范围2.1-12 mg / dl）。对于没有代谢综合征的受试者，代谢综合征患者的平均SUA为6.82±1.62 mg / dl（范围2.1-10 mg / dl）和5.45±1.59 mg / dl（范围2.1-12 mg / dl）。与不吸烟者相比，吸烟者的SUA水平显着更高（6.36±1.78对5.69±1.67，P = 0.05）。 SUA与NIH卒中量表评分之间存在显着的正相关（P≤0.05）。死者的SUA水平明显高于出院者（P = 0.00）。结论：SUA可以作为卒中风险增加的标志。此外，SUA也可用于中风后的危险分层。doi：10.4021 / jnr71w

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