...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the “Magenta osteoarthritis study”
【24h】

Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the “Magenta osteoarthritis study”

机译：骨关节炎随访中的生物标志物，II型胶原蛋白，氨基葡萄糖和硫酸软骨素：“洋红色骨关节炎研究”

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

class="Heading">Background class="Para">The purpose of the present study was to determine relationship between disease activity, systemic markers of cartilage degradation, urinary C-terminal cross-linking telopeptides of type II collagen (uCTX-II), and bone degradation, urinary C-terminal cross-linking telopeptides of type I collagen (uCTX-I), structural progression of osteoarthritis (OA) and potential therapeutic efficacy of type II collagen (COLLII) in combination with glucosamine and chondroitin sulfate (GC). class="Heading">Materials and methods class="Para">An observational retrospective study, 1-year follow-up, on 104 patients with OA (nodular osteoarthritis of the hand, erosive osteoarthritis of the hand, EOA, osteoarthritis of the knee or hip) who were treated with GC or glucosamine, chondroitin sulfate and collagen type II (GCC). The following information was collected at entry: demographics, BMI, characteristics of OA, patient global assessment (VAS), C-terminal cross-linking telopeptides of collagen types I (uCTX-I) and II (uCTX-II) and radiographs. After 6 months: VAS, uCTX-I and uCTX-II. After 1 year: VAS, uCTX-I, uCTX-II and radiographs. class="Heading">Results class="Para">After 6 months and 1 year of treatment VAS, uCTX-I and uCTX-II mean values were significantly lower than the baseline. 57 were treated with GCC and 47 with GC. The group that received GCC showed a similar VAS mean value after 6 months and 1 year when compared with the group treated with GC. uCTX-I and uCTX-II mean level was lower in the group treated with GCC (P 0.05). Radiological score (Kellgren and Lawrence summarized score for hands) after 1 year showed a reduced progression compared to the baseline in the hand osteoarthritis group, especially after GCC treatment (P 0.05). Finally, uCTX-I has better correlation with radiological score and with GC in the EOA subgroup (Pearson index: R = 0.44). class="Heading">Conclusions class="Para">(a) uCTX-I and uCTX-II proved to be useful biomarkers in OA monitoring; (b) uCTX-I is better correlated with hand EOA and could represent a potential further marker to assess the evolution of EOA bone damage; (c) GC slow down OA progression; (d) finally COLLII could represent a further protective factor in OA cartilage.
机译：class =“ Heading”>背景 class =“ Para”>本研究的目的是确定疾病活动，软骨降解的系统性标志物，尿的C末端交联端粒之间的关系。 II型胶原（uCTX-II）和骨降解，I型胶原的尿C端交联端肽（uCTX-I），骨关节炎（OA）的结构进展以及II型胶原（COLLII）的潜在治疗功效 class =“ Heading”>材料和方法 class =“ Para”>，是一项观察性回顾性研究，为期1年，随访时间为： 104例OA（手状结节性骨关节炎，手部糜烂性骨关节炎，EOA，膝盖或髋部骨关节炎）接受了GC或氨基葡萄糖，硫酸软骨素和II型胶原（GCC）治疗的患者。进入时收集了以下信息：人口统计学，BMI，OA特征，患者总体评估（VAS），I型胶原蛋白（uCTX-I）和II型胶原蛋白（uCTX-II）的C末端交联端肽和X线照片。 6个月后：VAS，uCTX-I和uCTX-II。 1年后：VAS，uCTX-I，uCTX-II和X光片。 class =“ Heading”>结果 class =“ Para”>经过6个月和1年的VAS治疗，uCTX-I和uCTX-II平均值显着低于基线。 GCC处理了57个，GC处理了47个。与接受GC治疗的组相比，接受GCC治疗的组在6个月和1年后显示出相似的VAS平均值。在接受GCC治疗的组中，uCTX-I和uCTX-II的平均水平较低（ P <0.05）。与手部骨关节炎组的基线相比，一年后的放射学评分（Kellgren和Lawrence总结为手的评分）显示出进展降低，尤其是在GCC治疗后（ P <0.05）。最后，uCTX-I与EOA子组的放射学评分和GC有更好的相关性（皮尔森指数： R = 0.44）。 class =“ Heading” >结论 class =“ Para”>（a）uCTX-I和uCTX-II被证明是在OA监测中有用的生物标志物; （b）uCTX-I与手部EOA的相关性更好，并且可能代表了评估EOA骨损伤演变的潜在潜在标志物; （c）GC减慢了OA进展; （d）最后，COLLII可能是OA软骨的另一个保护因子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号