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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Systematized water content calculation in cartilage using T1-mapping MR estimations: design and validation of a mathematical model
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Systematized water content calculation in cartilage using T1-mapping MR estimations: design and validation of a mathematical model

机译：使用T1映射MR估算系统地计算软骨中的水分含量：数学模型的设计和验证

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Up to 80 % of cartilage is water; the rest is collagen fibers and proteoglycans. Magnetic resonance (MR) T1-weighted measurements can be employed to calculate the water content of a tissue using T1 mapping. In this study, a method that translates T1 values into water content data was tested statistically. To develop a predictive equation, T1 values were obtained for tissue-mimicking gelatin samples. 1.5 T MRI was performed using inverse angle phase and an inverse sequence at 37 (±0.5) °C. Regions of interest were manually delineated and the mean T1 value was estimated in arbitrary units. Data were collected and modeled using linear regression. To validate the method, articular cartilage from six healthy pigs was used. The experiment was conducted in accordance with the Danish Animal Experiment Committee. Double measurements were performed for each animal. Ex vivo, all water in the tissue was extracted by lyophilization, thus allowing the volume of water to be measured. This was then compared with the predicted water content via Lin’s concordance correlation coefficient at the 95 % confidence level. The mathematical model was highly significant when compared to a null model (p  0.0001). 97.3 % of the variation in water content can be explained by absolute T1 values. Percentage water content could be predicted as 0.476 + (T1 value) × 0.000193 × 100 %. We found that there was 98 % concordance between the actual and predicted water contents. The results of this study demonstrate that MR data can be used to predict percentage water contents of cartilage samples. 3 (case-control study).
机译：软骨中多达80％是水;其余的是胶原纤维和蛋白聚糖。可以使用磁共振（MR）T1加权测量来使用T1映射计算组织的水分含量。在这项研究中，对将T1值转换为水含量数据的方法进行了统计测试。为了建立预测方程，获得了模拟组织的明胶样品的T1值。在37（±0.5）°C下使用反角相位和反序列进行1.5 T MRI。手动划定了感兴趣的区域，并以任意单位估算了平均T1值。收集数据并使用线性回归建模。为了验证该方法，使用了六只健康猪的关节软骨。实验是根据丹麦动物实验委员会进行的。对每只动物进行两次测量。离体时，通过冻干提取组织中的所有水，因此可以测量水的体积。然后通过Lin的一致性相关系数将其与95％置信度下的预测含水量进行比较。与零模型（p <0.0001）相比，数学模型非常重要。水分含量变化的97.3％可以用绝对T1值解释。含水率百分比可以预测为0.476 +（T1值）×0.000193×100％。我们发现实际含水量与预测含水量之间有98％的一致性。这项研究的结果表明，MR数据可用于预测软骨样品中水分的百分比。 3（病例对照研究）。

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