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首页> 外文期刊>Journal of pharmaceutical care. >Major Interaction between Warfarin and Na Valproate: A Case Report
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Major Interaction between Warfarin and Na Valproate: A Case Report

机译：华法林与丙戊酸钠之间的主要相互作用：一例报告

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Abstract: Warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties.Na Valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. Interaction between Warfarin and psychotropic drugs including Valproate are important and perhaps under recognized. In this report, we present a 48 year old female patient with chief complaints of abdominal pain, tea-color urine, blurred vision and headache. She had been suffering from “migraine headache” for 15 years that was relatively well controlled with Na Valproate 200mg twice daily. She was experienced a deep vein thrombosis (DVT) following oral contraceptive. For management of DVT, she was received Warfarin 5mg/day which was increased to 7.5 mg /day after 2 weeks. Three days after this increment of dose, her Prothrombin Time (PT) rose to 35.3 seconds (three times of normal value) and evidences of bleeding including hematuria and hematemesis were observed. Based on the history and laboratory findings, “Warfarin toxicity” was the first impression and she was treated with fresh frozen plasma and vitamin K with a well recovery. This experience emphasizes the clinical significant interaction between Warfarin and Na Valproate, which may take place even with the usual doses of each agent.
机译：摘要：华法林是临床实践中最常用的口服抗凝药，药代动力学性质之间存在极高的相互间和内部差异。广谱抗惊厥药Na Valproate以其酶抑制特性和蛋白质结合位点的置换而闻名。 。华法林与包括丙戊酸在内的精神药物之间的相互作用很重要，也许尚未得到认可。在本报告中，我们介绍了一位48岁的女性患者，主要表现为腹痛，茶色尿液，视力模糊和头痛。她患有“偏头痛”已有15年之久，每天服用200mg丙戊酸钠则可以控制相对较好。口服避孕药后，她经历了深静脉血​​栓形成（DVT）。为了控制DVT，她接受了华法林5毫克/天的剂量，并在2周后增加到7.5毫克/天。剂量增加三天后，她的凝血酶原时间（PT）升至35.3秒（正常值的三倍），并观察到有血尿和呕血的出血迹象。根据病史和实验室检查结果，“华法林毒性”是第一印象，她接受了新鲜的冷冻血浆和维生素K治疗，恢复良好。这项经验强调了华法林与丙戊酸钠之间的临床上显着的相互作用，即使使用通常剂量的每种药物也可能发生这种相互作用。

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