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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >How four and twelve weeks of implantation affect the strength and stiffness of a tendon graft securely fixed in a bone tunnel: a study of Evolgate fixation in an extra-articular model ovine model
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How four and twelve weeks of implantation affect the strength and stiffness of a tendon graft securely fixed in a bone tunnel: a study of Evolgate fixation in an extra-articular model ovine model

机译：植入四到十二周如何影响牢固固定在骨隧道中的腱移植物的强度和刚度：在关节外模型羊模型中对Evolgate固定的研究

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摘要

Healing of a tendon graft to a bone tunnel is slower than the healing of a bone plug. Therefore, the device chosen for hamstring fixation may need to maintain its strength and stiffness longer than the device chosen for bone-tendon-bone fixation. We evaluated, in an extraarticular ovine model, how 4 and 12 weeks of implantation affect the strength of a tendon graft fixed to bone with the Evolgate. The long digital extensor tendon was transplanted and fixed with the Evolgate into a 30-mm long, 8 mm diameter bone tunnel drilled in the tibial metaphysis of both posterior limbs of 15 skeletally mature Suffolk sheep. Immediately after implantation, and 4 and 12 weeks later, biomechanical cyclic load tests in 50 N increments were performed until failure to evaluate the ultimate failure load (UFL). Histological analysis was also performed at 4 and 12 weeks. Biomechanical tests revealed a UFL of 339±120 N at time 0, and increases to 635±19 N (4 weeks) and to 867±80 N (12 weeks). The differences between all 3 groups were significant (p0.001, paired t test). The histological evaluation showed a layer of cellular, fibrous tissue between the tendon and the bone, along the length of the bone tunnel; this layer progressively matured and reorganized during the healing process. The collagen fibers that attached the tendon to the bone resembled Sharpey’s fibers. The strength of the interface significantly and progressively increased between weeks 4 and 12 after transplantation, and was associated with a degree of bone ingrowth noted histologically. The use of the Evolgate seems not to interfere with the bone ingrowth after implantation, allowing an improvement in strength of the bonetendon- device complex.
机译：肌腱移植到骨隧道的愈合比骨栓的愈合慢。因此，选择用于腿筋固定的设备可能需要比选择用于骨腱-骨固定的设备保持更长的强度和刚度。我们在关节外绵羊模型中评估了植入4周和12周后，如何通过Evolgate固定固定在骨骼上的腱移植物的强度。将长的指伸肌腱移植并与Evolgate固定在一起，在15具骨骼成熟的萨福克羊的后肢胫骨干15端钻出的30毫米长，8毫米直径的骨隧道中。植入后立即以及4周和12周后，以50 N的增量进行生物力学循环载荷测试，直到无法评估最终破坏载荷（UFL）。在第4周和第12周也进行了组织学分析。生物力学测试显示，UFL在时间0时为339±120 N，并增加到635±19 N（4周）和867±80 N（12周）。所有三组之间的差异是显着的（p <0.001，配对t检验）。组织学评估显示，沿着骨隧道的长度，在肌腱和骨骼之间有一层细胞性纤维组织。在愈合过程中，该层逐渐成熟并重新组织。将肌腱附着在骨头上的胶原纤维类似于夏普的纤维。移植后第4周至第12周之间，界面强度显着并逐渐增加，并且与组织学上注意到的骨向内生长程度相关。使用Evolgate似乎不会干扰植入后的骨骼向内生长，从而可以改善骨骼肌设备复合体的强度。

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