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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Effectiveness of synthetic hydroxyapatite versus Persian Gulf coral in an animal model of long bone defect reconstruction
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Effectiveness of synthetic hydroxyapatite versus Persian Gulf coral in an animal model of long bone defect reconstruction

机译：合成羟基磷灰石与波斯湾珊瑚在长骨缺损重建动物模型中的有效性

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class="Heading">Background class="Para">There is a continuing search for bone substitutes to avoid or minimize the need for autogenous bone grafts. Hydroxyapatite, a crystalline phase of calcium phosphate found naturally in bone minerals, has shown tremendous promise as a graft material. Coral is an osteoconductive material used as a bone graft extender. This study examined the effect of hydroxyapatite and Persian Gulf coral on osteogenesis in?vivo using a rabbit model of bone healing. class="Heading">Materials and methods class="Para">A critical-size defect of 10?mm elongation was created in the radial diaphysis of 36 rabbits and supplied with either hydroxyapatite or coral or left empty (control group). Radiographs of each forelimb were taken postoperatively on day?1 and then at 2, 4, 6, and 8?weeks postinjury to evaluate bone formation, union, and remodeling of the defect. The operated radiuses were removed on the 56th postoperative day and were grossly and histopathologically evaluated. In addition, biomechanical testing was conducted on the operated and normal forelimbs of half of the animals of each group. class="Heading">Results class="Para">In radiological evaluation, bone formation and union were significantly superior in the coral and hydroxyapatite groups in comparison with the control group on the 42nd and 56th day postinjury (P??0.05). There were no statistical differences between groups in remodeling criteria at the 56th day postinjury (P??0.05). In histopathological evaluation, the union scores of the rabbits administered hydroxyapatite or coral were statistically superior to those of the animals of the control group on the 56th day postinjury (P??0.05). In biomechanical evaluation, the control group showed weakness of biomechanical properties in comparison with the coral and hydroxyapatite groups (P??0.05). class="Heading">Conclusions class="Para">According to this study, significant difference was not observed between hydroxyapatite and natural coral and these two materials were significantly better than the control group at 8?weeks postinjury.
机译：class =“ Heading”>背景 class =“ Para”>人们一直在寻找替代骨，以避免或最小化对自体骨移植的需求。羟基磷灰石是天然存在于骨矿物质中的磷酸钙的结晶相，已显示出作为接枝材料的巨大希望。珊瑚是一种骨传导材料，用作骨移植扩展剂。本研究使用兔骨愈合模型研究了羟基磷灰石和波斯湾珊瑚对体内成骨的影响。 class =“ Heading”>材料和方法 class =“ Para” > 36只家兔的骨中出现了一个10μmm伸长的临界尺寸缺损，并提供了羟基磷灰石或珊瑚或空置（对照组）。术后第1天，然后在受伤后第2、4、6和8周对每个前肢进行X射线照相，以评估缺损的骨形成，愈合和重塑。术后第56天切除手术半径，并对其进行总体和组织病理学评估。此外，还对每组一半动物的手术前肢和正常前肢进行了生物力学测试。 class =“ Heading”>结果 class =“ Para”>在放射学评估中在受伤后第42天和第56天，珊瑚和羟基磷灰石组的骨形成和联合明显优于对照组（ P ？<？0.05）。损伤后第56天，两组的重塑标准之间无统计学差异（ P ？>？0.05）。在组织病理学评估中，在受伤后第56天，给予羟基磷灰石或珊瑚的兔子的联合得分在统计学上优于对照组动物（ P ？<？0.05） 。在生物力学评估中，与珊瑚和羟基磷灰石组相比，对照组的生物力学特性较弱（ P ？<？0.05）。 class =“ Heading “>结论 class =” Para“>，根据这项研究，羟基磷灰石与天然珊瑚之间没有观察到显着差异，并且在受伤后8周，这两种材料均明显优于对照组。

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