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首页> 外文期刊>Journal of obesity >Trial Characteristics and Appropriateness of Statistical Methods Applied for Design and Analysis of Randomized School-Based Studies Addressing Weight-Related Issues: A Literature Review
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Trial Characteristics and Appropriateness of Statistical Methods Applied for Design and Analysis of Randomized School-Based Studies Addressing Weight-Related Issues: A Literature Review

机译：统计方法的试验特性和适当性，用于设计和分析基于权重问题的随机校本研究：文献综述

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Objective. To evaluate whether clustering effects, often quantified by the intracluster correlation coefficient (ICC), were appropriately accounted for in design and analysis of school-based trials. Methods. We searched PubMed and extracted variables concerning study characteristics, power analysis, ICC use for power analysis, applied statistical models, and the report of the ICC estimated from the observed data. Results. papers were identified, and papers were included for evaluation. Overall, only a minority (21.5%) of studies incorporated ICC values for power analysis, fewer studies (8.3%) reported the estimated ICC, and 68.6% of studies applied appropriate multilevel models. A greater proportion of studies applied the appropriate models during the past five years (2013–2017) compared to the prior years (74.1% versus 63.5%, ). Significantly associated with application of appropriate models were a larger number of schools (), a larger sample size (), longer follow-up (), and randomization at a cluster level () and so were studies that incorporated the ICC into power analysis () and reported the estimated ICC (). Conclusion. Although application of appropriate models has increased over the years, consideration of clustering effects in power analysis has been inadequate, as has report of estimated ICC. To increase rigor, future school-based trials should address these issues at both the design and analysis stages.
机译：目的。为了评估通常通过集群内相关系数（ICC）量化的集群效应，是否在学校试验的设计和分析中得到适当考虑。方法。我们搜索了PubMed，并提取了有关研究特征，功效分析，ICC用于功效分析的变量，应用的统计模型以及从观察到的数据估计的ICC报告。结果。确定论文，并包括论文以进行评估。总体而言，只有少数（21.5％）的研究纳入了ICC值进行功率分析，较少的研究（8.3％）报告了估计的ICC，而68.6％的研究则采用了适当的多级模型。与前几年相比，在过去的五年（2013-2017年）中，有更多的研究采用了适当的模型（74.1％对63.5％）。与适当模型的应用显着相关的是更多的学校（），更大的样本量（），更长的随访时间（）和聚类水平的随机化（），将ICC纳入功效分析的研究也是如此（ ），并报告估算的ICC（）。结论。尽管多年来使用适当的模型的情况有所增加，但正如估计的ICC的报告一样，在功率分析中对聚类效应的考虑还不够。为了提高严格性，将来在校内进行的试验应在设计和分析阶段都解决这些问题。

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