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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Long-term clinical results and MRI changes after autologous chondrocyte implantation in the knee of young and active middle aged patients
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Long-term clinical results and MRI changes after autologous chondrocyte implantation in the knee of young and active middle aged patients

机译：年轻活跃的中年患者膝关节自体软骨细胞植入后的长期临床结果和MRI变化

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Autologous chondrocyte implantation (ACI) represents a valid surgical option for symptomatic full-thickness chondral lesions of the knee. Here we report long-term clinical and MRI results of first-generation ACI. Fifteen patients (mean age 21.3 years) underwent first-generation ACI for symptomatic chondral defects of the knee between 1997 and 2001. The mean size of the lesions was 5.08 cm2 (range 2–9 cm2). Patients were evaluated using the International Knee Documentation Committee (IKDC) Knee Examination Form, the Tegner Activity Scale, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). High-resolution MRI was used to analyze the repair tissue with nine variables (the MOCART scoring system). The mean follow-up period was 148 months (range 125–177 months). ACI resulted in substantial improvements in all clinical outcome parameters, even as much as 12 years after implantation. A significant decrease in the MOCART score was recorded at final measurement. Reoperation was required in 2 patients; failure was caused by partial detachment of the graft in both cases. Autologous chondrocyte implantation is an effective and durable solution for the treatment of large, full-thickness cartilage and osteochondral lesions, even in young and active middle-aged patients. High-resolution MRI is a useful and noninvasive method for evaluating the repaired tissue. IV.
机译：自体软骨细胞植入（ACI）代表有症状的膝关节全层软骨损伤的有效手术选择。在这里，我们报告第一代ACI的长期临床和MRI结果。 1997年至2001年之间，有15例患者（平均年龄21.3岁）接受了第一代ACI膝关节有症状的软骨缺损。病灶的平均大小为5.08 cm2（范围为2-9 cm2）。使用国际膝关节文献委员会（IKDC）膝关节检查表，Tegner活动量表以及膝关节损伤和骨关节炎结果评分（KOOS）对患者进行评估。高分辨率MRI用于分析具有9个变量的修复组织（MOCART评分系统）。平均随访期为148​​个月（范围125-177个月）。 ACI甚至在植入后长达12年的时间里都对所有临床结局参数产生了实质性的改善。在最终测量时，MOCART得分显着下降。 2例患者需要再次手术;在两种情况下，失败都是由移植物的部分脱落引起的。自体软骨细胞植入是一种有效而持久的解决方案，即使在年轻且活跃的中年患者中，也可用于治疗大而全厚度的软骨和骨软骨损伤。高分辨率MRI是评估修复组织的有用且无创的方法。 IV。

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