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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country
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Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country

机译：地中海国家膝或髋骨关节炎患者的维生素D状况

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Vitamin D plays an important role in bone mineralization, remodeling, and maintenance and therefore its deficiency may be implicated in the pathogenesis of osteoarthritis (OA). Vitamin D status was evaluated in patients with knee or hip OA scheduled for joint replacement. The impact of anthropometric parameters such as gender, age, and body mass index on vitamin D levels was also examined. The study was conducted in a Mediterranean country (Greece). We included 164 patients with knee or hip OA scheduled for joint replacement in this study. Serum levels of 25-hydroxyvitamin D (vitamin D) were measured in routine blood samples taken from the patients at their pre-admission visit, a week before the operation, using radioimmunoassay. The majority of patients were vitamin D deficient (81.7 %); 15.2 % of them were vitamin D insufficient (hypovitaminosis). Only 3 % of patients were vitamin D sufficient. There was a significantly positive association between vitamin D levels and male gender. These findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece. Many other possible predisposing factors for OA should be taken into consideration. Whether treatment with vitamin D supplements may provide beneficial effects to these patients and the stage of disease in which this treatment should commence remains an issue for further scientific investigation. Level IV.
机译：维生素D在骨骼矿化，重塑和维持中起着重要作用，因此维生素D的缺乏可能与骨关节炎（OA）的发病机理有关。对计划进行关节置换的膝关节或髋关节OA患者的维生素D状态进行了评估。还检查了人体测量学参数（如性别，年龄和体重指数）对维生素D水平的影响。该研究在地中海国家（希腊）进行。我们纳入了164例计划进行关节置换的膝或髋OA患者。在患者入院前的常规血液样本中，在手术前一周使用放射免疫测定法测量了血清中25-羟基维生素D（维生素D）的水平。大多数患者维生素D缺乏（81.7％）;其中15.2％的维生素D不足（维生素缺乏症）。只有3％的患者维生素D足够。维生素D水平与男性之间存在显着正相关。这些发现表明，患有膝关节或髋关节OA的维生素D缺乏症患者比例很高，考虑到希腊北部每年的日照量很高，这是出乎意料的。 OA还应考虑许多其他可能的诱发因素。维生素D补充剂的治疗是否可以为这些患者提供有益的效果，以及应该开始这种治疗的疾病阶段仍是进一步科学研究的问题。第四级。

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