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首页> 外文期刊>Journal of Otology >Suprathreshold compound action potential amplitude as a measure of auditory function in cochlear implant users
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Suprathreshold compound action potential amplitude as a measure of auditory function in cochlear implant users

机译：阈上复合动作电位振幅作为人工耳蜗使用者听觉功能的量度

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Electrically evoked compound action potential (eCAP) amplitudes elicited at suprathreshold levels were assessed as a measure of the effectiveness of cochlear implant (CI) stimulation. Twenty-one individuals participated; one was excluded due to facial stimulation during eCAP testing. For each participant, eCAPs were elicited with stimulation from seven electrodes near the upper limit of the individual's electrical dynamic range. A reduced-channel CI program was created using those same seven electrodes, and participants performed a vowel discrimination task. Consistent with previous reports, eCAP amplitudes varied across tested electrodes; the profiles were unique to each individual. In 6 subjects (30%), eCAP amplitude variability was partially explained by the impedance of the recording electrode. The remaining amplitude variability within subjects, and the variability observed across subjects could not be explained by recording electrode impedance. This implies that other underlying factors, such as variations in neural status across the array, are responsible. Across-site mean eCAP amplitude was significantly correlated with vowel discrimination scores (r 2 ?=?0.56). A single eCAP amplitude measured from the middle of the array was also significantly correlated with vowel discrimination, but the correlation was weaker (r 2 ?=?0.37), though not statistically different from the across-site mean. Normalizing each eCAP amplitude by its associated recording electrode impedance did not improve the correlation with vowel discrimination (r 2 ?=?0.52). Further work is needed to assess whether combining eCAP amplitude with other measures of the electrode-neural interface and/or with more central measures of auditory function provides a more complete picture of auditory function in CI recipients.
机译：阈上水平引起的电诱发复合动作电位（eCAP）幅度被评估为耳蜗植入（CI）刺激效果的量度。二十一个人参加;在eCAP测试期间，由于面部刺激而排除了一名。对于每个参与者，在靠近个人电动态范围上限的七个电极的刺激下引发eCAP。使用相同的七个电极创建了通道减少的CI程序，参与者执行了元音识别任务。与以前的报告一致，eCAP幅度在被测电极之间有所不同。每个人的个人资料都是唯一的。在6位受试者（30％）中，eCAP幅度变异性部分由记录电极的阻抗解释。记录电极阻抗无法解释受试者体内剩余的振幅变异性以及受试者之间观察到的变异性。这暗示着其他潜在因素，例如整个阵列中神经状态的变化，也是造成这种情况的原因。跨站点的平均eCAP幅度与元音辨别力得分显着相关（r 2？=？0.56）。从阵列中间测得的单个eCAP幅度也与元音辨别力显着相关，但相关性较弱（r 2？=？0.37），尽管与跨站均值在统计学上没有差异。通过其相关的记录电极阻抗对每个eCAP幅度进行归一化，并不能改善与元音辨别的相关性（r 2？=？0.52）。需要进一步的工作来评估是否将eCAP振幅与电极-神经界面的其他测量值和/或与听觉功能的更多集中测量值相结合是否可以提供CI接受者听觉功能的更完整描述。

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