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首页> 外文期刊>Journal of Pharmaceutical Policy and Practice >Antibiotic prescribing in women during and after delivery in a non-teaching, tertiary care hospital in Ujjain, India: a prospective cross-sectional study
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Antibiotic prescribing in women during and after delivery in a non-teaching, tertiary care hospital in Ujjain, India: a prospective cross-sectional study

机译：在印度乌j的一家不教学的三级医院分娩过程中和分娩后的妇女中的抗生素处方：一项前瞻性横断面研究

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Objectives Antibacterial drugs (hereafter referred to as antibiotics) are crucial to treat infections during delivery and postpartum period to reduce maternal mortality. Institutional deliveries have the potential to save lives of many women but extensive use of antibiotics, add to the development and spread of antibiotic resistance. The aim of this study was to present antibiotic prescribing among inpatients during and after delivery in a non-teaching, tertiary care hospital in the city of Ujjain, Madhya Pradesh, India. Methods A prospective cross-sectional study was conducted including women having had either a vaginal delivery or a cesarean section in the hospital. Trained nursing staff collected the data on daily bases, using a specific form attached to each patient file. Statistical analysis, including bivariate and multivariable logistic regression was conducted. Results Of the total 1077 women, 566 (53%) had a vaginal delivery and 511 (47%) had a cesarean section. Eighty-seven percent of the women that had a vaginal delivery and 98% of the women having a cesarean section were prescribed antibiotics. The mean number of days on antibiotics in hospital for the women with a vaginal delivery was 3.1 (±1.7) and for the women with cesarean section was 6.0 (±2.5). Twenty-eight percent of both the women with vaginal deliveries and the women with cesarean sections were prescribed antibiotics at discharge. The most commonly prescribed antibiotic group in the hospital for both the women that had a vaginal delivery and the women that had a cesarean section were third-generation cephalosporins (J01DD). The total number of defined daily doses (DDD) per100 bed days for women that had a vaginal delivery was 101, and 127 for women that had a cesarean section. Conclusions The high percentage of women having had a vaginal delivery that received antibiotics and the deviation from recommendation for cesarean section in the hospital is a cause of concern. Improved maternal health and rational use of antibiotics are intertwined. Specific policy and guidelines on how to prescribe antibiotics during delivery at health care facilities are needed. Additionally, monitoring system of antibiotic prescribing and resistance needs to be developed and implemented.
机译：目的抗菌药物（以下称为抗生素）对于治疗分娩期和产后感染，降低孕产妇死亡率至关重要。机构分娩有可能挽救许多妇女的生命，但广泛使用抗生素会增加抗生素耐药性的发生和扩散。这项研究的目的是介绍印度中央邦乌贾因市一家不教学的三级医院分娩过程中和分娩后的患者中的抗生素处方。方法进行了一项前瞻性横断面研究，其中包括在医院进行阴道分娩或剖宫产的妇女。受过训练的护理人员使用每个患者档案所附的特定表格，每天收集数据。进行了统计分析，包括双变量和多变量逻辑回归。结果在1077名妇女中，有566名（53％）进行了阴道分娩，其中有511名（47％）进行了剖宫产。接受阴道分娩的女性中有87％接受剖宫产的女性中有98％接受了抗生素处方。阴道分娩妇女的平均住院天数为3.1（±1.7）天，剖宫产妇女的平均抗生素天数为6.0（±2.5）。阴道分娩的妇女和剖宫产的妇女中有28％在出院时开了抗生素。对于阴道分娩的妇女和剖宫产的妇女，医院中最常用的抗生素组是第三代头孢菌素（J01DD）。阴道分娩的妇女每100个床日定义的日剂量（DDD）总数为101，剖宫产妇女为127。结论阴道分娩的妇女中有很高比例的妇女接受了抗生素，并且医院对剖宫产建议的偏离也引起了人们的关注。改善产妇保健和合理使用抗生素是相互联系的。需要有关在医疗机构分娩期间如何开抗生素的具体政策和指南。另外，需要开发和实施抗生素处方和耐药性监测系统。

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