Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods

Ai-Zhi Wu; Chao-Zhan Lin; Ya-Jing Zhai; Jia-Lin Zhuo; Chen-Chen Zhu

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Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods

机译：分光光度法研究两种苯基乙醛糖苷与牛血清白蛋白的相互作用

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Two phenylethanoid glycosides, acteoside and forsythoside B, were first isolated from the traditional Chinese herb Callicarpa peii H.T. Chang. The interaction between the two phenylethanoid glycosides and bovine serum albumin (BSA) was investigated by fluorescence, UV–vis absorbance and circular dichroism (CD). The results showed that the quenching mechanism in the drug–BSA binary systems was a combination of static quenching and non-radiative energy transfer. Displacement experiments confirmed that the drug bound to the site I of BSA. UV–vis and CD measurements indicated that the binding of the drug to BSA induced conformational changes in BSA.

机译：首先从传统中草药Callicarpa peii H.T.中分离出两种苯乙类乙醇苷，即acteoside和forsythosideB。昌通过荧光，紫外可见吸收和圆二色性（CD）研究了两种苯乙醇样苷和牛血清白蛋白（BSA）之间的相互作用。结果表明，药物-BSA二元系统的猝灭机理是静态猝灭和非辐射能量转移的结合。置换实验证实该药物与BSA的I位结合。紫外可见和CD测量表明该药物与BSA的结合可引起BSA的构象变化。

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《Journal of Pharmaceutical Analysis》 |2013年第1期|共5页
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Ai-Zhi Wu; Chao-Zhan Lin; Ya-Jing Zhai; Jia-Lin Zhuo; Chen-Chen Zhu;
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中图分类药学;
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1. Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods [J] . Ai-Zhi Wu, Chao-Zhan Lin, Ya-Jing Zhai, 药物分析学报（英文） . 2013,第001期

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4. Study on the Interaction between 3, 5-Dinitrobenzoic Acid and Bovine Serum Albumin by Fluorescence Spectroscopic Method [C] . Xiangyu Cao, Jianli LIU, Xiuli Lu International Conference on Chemical Engineering and Advanced Materials . 2011

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5. Characterization of interaction forces between bovine serum albumin and self-assembled monolayers relating to protein adhesion. [D] . Pham, Bich-Van C. 2009

机译：牛血清白蛋白和自组装单层与蛋白质粘附有关的相互作用力的表征。
6. Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods [O] . Ai-Zhi Wu, Chao-Zhan Lin, Ya-Jing Zhai, 2013

机译：光谱法研究两种苯基乙醛糖苷与牛血清白蛋白的相互作用
7. Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods [O] . Wu Ai-Zhi, Lin Chao-Zhan, Zhai Ya-Jing, 2013

机译：光谱法研究两种苯基乙醛糖苷与牛血清白蛋白的相互作用

Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods

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