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首页> 外文期刊>Journal of Pharmaceutical Analysis >Analysis of spironolactone residues in industrial wastewater and in drug formulations by cathodic stripping voltammetry
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Analysis of spironolactone residues in industrial wastewater and in drug formulations by cathodic stripping voltammetry

机译：阴极溶出伏安法分析工业废水和药物制剂中螺内酯残留

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The redox behavior of spironolactone (SP) drug in Britton–Robinson (BR) buffer of pH 2–11 was investigated by differential pulse cathodic stripping voltammetry (DPCSV) and cyclic voltammetry (CV) at hanging mercury dropping electrode (HMDE). At pH 9–10.5, the DPCSV of SP drug showed two cathodic peaks at ?1.15 and ?1.38V at the HMDE vs. Ag/AgCl reference electrode. In the CV, at pH 9–10, the dependence of the cathodic peak current, I p , c and peak potential, E p , c of the second peak ( E p , c 2 ) on the scan rate ( ν ) and on the depolizer (SP) concentrations was typical of an electrode coupled (EC) chemical reaction type mechanism. The plot of I p , c at ?1.380V of the DPCSV vs. SP concentration at pH 9 was linear over the concentration range of 1.2×10 ?10 ?9.6×10 ?7 M. The lower limit of detection (LLOD) and limit of quantification (LOQ) of the drug were 1.1×10 ?11 and 4.14×10 ?11 M, respectively. The method was successfully applied for the analysis of SP residues in industrial wastewater, in pure form (98.2±3.1%) and in drug formulations e.g. Aldactone? tablet (98.35±2.9%).The method was validated by comparison with HPLC and the official data methods.
机译：通过差分脉冲阴极溶出伏安法（DPCSV）和循环伏安法（CV）在悬挂汞滴电极（HMDE）上研究了螺内酯（SP）药物在pH 2-11的Britton-Robinson（BR）缓冲液中的氧化还原行为。在pH值9-10.5时，SP药物的DPCSV在HMDE与Ag / AgCl参比电极上在〜1.15和〜1.38V处显示两个阴极峰。在CV中，pH为9-10时，第二个峰（E p，c 2）的阴极峰电流I p，c和峰电位E p，c与扫描速率（ν）和去极化剂（SP）的浓度是电极耦合（EC）化学反应型机理的典型特征。在pH值为9的条件下，DPCSV在1.380V处的I p，c相对于SP浓度的曲线在1.2×10〜10〜9.6×10〜7 M的浓度范围内呈线性关系。检测下限（LLOD）和该药物的定量限（LOQ）分别为1.1×10？11 M和4.14×10？11M。该方法已成功地用于分析工业废水中纯净形式（98.2±3.1％）和药物配方中的SP残留量。 Aldactone？片剂（98.35±2.9％）。该方法与HPLC和官方数据方法进行了比较验证。

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