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首页> 外文期刊>Journal of Pharmaceutical Analysis >Electrooxidation of sulfanilamide and its voltammetric determination in pharmaceutical formulation, human urine and serum on glassy carbon electrode
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Electrooxidation of sulfanilamide and its voltammetric determination in pharmaceutical formulation, human urine and serum on glassy carbon electrode

机译：玻碳电极上药物制剂，人尿和血清中磺胺的电氧化及其伏安法测定

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For the first time,?sulfanilamide (SFD) was determined in otologic solution, human urine and serum by electroanalytical techniques on glassy carbon electrode (GCE). The cyclic voltammetry (CV) experiments showed an irreversible oxidation peak at +1.06V in 0.1mol/L BRBS (pH = 2.0) at 50mV/s. Different voltammetric scan rates (from 10 to 250mV/s) suggested that the oxidation of SFD on the GCE was a diffusion-controlled process. Square-wave voltammetry (SWV) method under optimized conditions showed a linear response to SFD from 5.0 to 74.7μmol/L (R = 0.999) with detection and quantification limits of 0.92 and 3.10μmol/L, respectively. The developed SWV method showed better results for detection limit and linear range than the chronoamperometry method. It has been successfully applied to determine SFD concentration in pharmaceutical formulation, human urine and serum?samples with recovery close to 100%.
机译：首次在玻璃碳电极（GCE）上通过电分析技术测定了眼科溶液，人尿和血清中的？磺胺（SFD）。循环伏安法（CV）实验显示，在50mV / s的0.1mol / L BRBS（pH = 2.0）中，+ 1.06V处有不可逆的氧化峰。不同的伏安扫描速率（从10到250mV / s）表明，在GCE上SFD的氧化是扩散控制的过程。在优化条件下，方波伏安法（SWV）显示对SFD的线性响应为5.0至74.7μmol/ L（R = 0.999），检测和定量限分别为0.92和3.10μmol/ L。与计时电流法相比，开发的SWV方法在检测限和线性范围方面显示出更好的结果。它已成功地用于测定药物制剂，人尿和血清样品中的SFD浓度，回收率接近100％。

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