Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge

Stephen Morgan; Stephanie Duguez; William Duddy

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Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge

机译：肌萎缩性侧索硬化症（ALS）中的个性化医学和分子相互作用网络：最新知识

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Multiple genes and mechanisms of pathophysiology have been implicated in amyotrophic lateral sclerosis (ALS), suggesting it is a complex systemic disease. With this in mind, applying personalized medicine (PM) approaches to tailor treatment pipelines for ALS patients may be necessary. The modelling and analysis of molecular interaction networks could represent valuable resources in defining ALS-associated pathways and discovering novel therapeutic targets. Here we review existing omics datasets and analytical approaches, in order to consider how molecular interaction networks could improve our understanding of the molecular pathophysiology of this fatal neuromuscular disorder.

机译：肌萎缩性侧索硬化症（ALS）涉及多种基因和病理生理机制，表明这是一种复杂的全身性疾病。考虑到这一点，可能有必要应用个性化医学（PM）方法为ALS患者量身定制治疗方案。分子相互作用网络的建模和分析可以代表定义ALS相关途径和发现新型治疗靶点方面的宝贵资源。在这里，我们回顾了现有的组学数据集和分析方法，以考虑分子相互作用网络如何改善我们对这种致命性神经肌肉疾病的分子病理生理学的理解。

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《Journal of Personalized Medicine》 |2018年第4期|共17页
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Stephen Morgan; Stephanie Duguez; William Duddy;
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中图分类临床医学;
关键词
ALSpersonalized medicinemolecular interaction networks;

机译：ALS个性化药物分子相互作用网络;

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1. Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis [J] . Alexander E. Volk, Jochen H. Weishaupt, Peter M. Andersen, Medizinische Genetik . 2018,第2期

机译：目前的知识和最近洞察肌营养侧面硬化症的遗传基础
2. Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates [J] . Marcuzzo Stefania, Terragni Benedetta, Bonanno Silvia, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2019,第1期

机译：来自G93A-SOD1肌营养侧硬化模型小鼠的培养的皮质神经元网络中的过度兴奋性及其分子相关性
3. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy [J] . M. Carolina Gallego Iradi, Judy C. Triplett, James D. Thomas, Scientific reports. . 2018,第1期

机译：Matrin 3编码与肌萎缩性侧索硬化症和肌病相关的突变的基因调控和蛋白质相互作用网络的表征
4. Directional brain functional interaction analysis in patients with amyotrophic lateral sclerosis [C] . Shahriari Y., Sellers E.W., McCane L.M., International IEEE/EMBS Conference on Neural Engineering . 2015

机译：肌萎缩性侧索硬化症患者的定向脑功能相互作用分析
5. The effects of long-term caloric restriction on molecular outcome measures in the copper/zinc-SOD mutant G93A mouse, an animal model of amyotrophic lateral sclerosis (ALS). [D] . Patel, Barkha P. 2009

机译：长期热量限制对铜/锌-SOD突变体G93A小鼠（一种肌萎缩性侧索硬化症（ALS）的动物模型）的分子结果测量的影响。
6. Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge [O] . Stephen Morgan, Stephanie Duguez, William Duddy 2018

机译：肌萎缩性侧索硬化症（ALS）中的个性化医学和分子相互作用网络：最新知识
7. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy [O] . M. Carolina Gallego Iradi, Judy C. Triplett, James D. Thomas, 2018

机译：基因调控和蛋白质相互作用网络的表征与肌营养侧颅骨菌和肌病有关的突变突变

Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge

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