...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Pharmacology and Pharmacotherapeutics >Protective role of glibenclamide against nicotinamide-streptozotocin induced nuclear damage in diabetic Wistar rats
【24h】

Protective role of glibenclamide against nicotinamide-streptozotocin induced nuclear damage in diabetic Wistar rats

机译：格列本脲对烟酰胺-链脲佐菌素诱导的糖尿病Wistar大鼠核损伤的保护作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective:To evaluate the protective effect of glibenclamide against the experimental diabetes-induced nuclear damage in Wistar rats.Materials and Methods:The anti-mutagenic effect of glibenclamide (0.5, 5 and 50 mg/kg, p.o daily for 4 weeks) was evaluated against the nicotinamide (NA)-streptozotocin (STZ) induced type-2 diabetes mellitus using bone marrow micronucleus and sperm abnormalities tests. The antioxidant status was tested by estimating the serum levels of lipid peroxidation (LPO), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx).Results:The results indicated that glibenclamide at 50 mg/kg decreased the frequency of micronuclei in erythrocytes (P < 0.05) and sperm shape abnormality (P < 0.01) besides enhancing the antioxidant status (P < 0.05) in the diabetic rats. However, glibenclamide treatment did not enhance the polychromatic and normochromatic erythrocytes (P/N) ratio and sperm count in the diabetic condition.Conclusion:The observations indicate that the glibenclamide has anti-mutagenic potential which could be related to the antioxidant effect and might also possess anti-proliferative property.
机译：目的：评价格列本脲对糖尿病大鼠Wistar大鼠实验性核损伤的保护作用。材料与方法：评估格列本脲（0.5、5和50 mg / kg，每天口服4周）的抗诱变作用。使用骨髓微核和精子异常测试针对烟酰胺（NA）-链脲佐菌素（STZ）诱导的2型糖尿病。通过估计血清脂质过氧化（LPO），过氧化氢酶（CAT），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的水平来测试其抗氧化状态。结果：结果表明，以50 mg / kg的格列本脲降低了糖尿病大鼠的红细胞微核（P <0.05）和精子形状异常（P <0.01）不仅增强了抗氧化剂的状态（P <0.05）。然而，在糖尿病条件下，格列本脲治疗并不能提高多色和常色红细胞（P / N）比和精子计数。结论：观察表明，格列本脲具有抗诱变潜力，可能与抗氧化作用有关，也可能具有抗增殖性能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号