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首页> 外文期刊>Journal of Pharmacology and Pharmacotherapeutics >Role of cinnarizine and nifedipine on anticonvulsant effect of sodium valproate and carbamazepine in maximal electroshock and pentylenetetrazole model of seizures in mice
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Role of cinnarizine and nifedipine on anticonvulsant effect of sodium valproate and carbamazepine in maximal electroshock and pentylenetetrazole model of seizures in mice

机译：桂那利嗪和硝苯地平对丙戊酸钠和卡马西平在小鼠最大癫痫发作模型中的惊厥作用

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Objective:To study the effect of calcium channel blockers (CCBs) cinnarizine and nifedipine on maximal electroshock (MES)-induced and pentylenetetrazole (PTZ)-induced convulsions and also their effect in combination with conventional antiepileptic drugs (CAED).Materials and Methods:For this study, Swiss albino mice were used. Effects of cinnarizine (30 mg/kg), nifedipine (5 mg/kg), sodium valproate (300 mg/kg) and carbamazepine (8 mg/kg) alone and in combination were studied in MES and PTZ seizure models. Abolition of hind limb tonic extension was an index of anticonvulsant activity in MES, while for PTZ seizures, failure to observe even a single episode of tonic spasm for 5 s duration for 1 h was the index. With this, percentage protection was calculated and statistical analysis was carried out using Fisher’s exact test (Ovvind Langsrud software, German version).Results:In MES seizures, augmented effects were obtained when cinnarizine was combined with sodium valproate, i.e. 100%. In PTZ-induced seizures, augmented effects were obtained when nifedipine was combined with sodium valproate, i.e. 100%. Thus, cinnarizine added to sodium valproate therapy produces significant protection against MES seizures while nifedipine added to sodium valproate therapy produces significant protection against PTZ seizures.Conclusion:The results provide a lead for potential benefit of adding CCBs to sodium valproate in the treatment of epilepsy, which needs to be explored further.
机译：目的：研究钙通道阻滞剂（CCBs）肉桂利嗪和硝苯地平对最大电击（MES）和戊四氮（PTZ）引起的惊厥的作用，以及与常规抗癫痫药（CAED）联合使用的作用。在这项研究中，使用了瑞士白化病小鼠。在MES和PTZ癫痫发作模型中分别研究了肉桂利嗪（30 mg / kg），硝苯地平（5 mg / kg），丙戊酸钠（300 mg / kg）和卡马西平（8 mg / kg）的作用。取消后肢强直性伸展是MES中抗惊厥活性的指标，而对于PTZ癫痫发作，即使在5小时的1小时内未观察到单次强直性痉挛也是该指标。这样，就可以计算出保护百分率，并使用Fisher精确检验（Ovvind Langsrud软件，德语版）进行统计分析。结果：在MES癫痫发作中，桂那利嗪与丙戊酸钠联合（即100％）可获得增强的作用。在PTZ诱发的癫痫发作中，硝苯地平与丙戊酸钠（即100％）合用时，效果增强。因此，在丙戊酸钠治疗中加入肉桂那利嗪可显着预防MES发作，而在丙戊酸钠治疗中加入硝苯地平对PTZ癫痫发作具有明显的保护作用。结论：该结果为在丙戊酸钠中添加CCBs治疗癫痫，有待进一步探讨。

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