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首页> 外文期刊>Journal of Pharmacology and Pharmacotherapeutics >Effect of vitamin E alone and in combination with lycopene on biochemical and histopathological alterations in isoproterenol-induced myocardial infarction in rats
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Effect of vitamin E alone and in combination with lycopene on biochemical and histopathological alterations in isoproterenol-induced myocardial infarction in rats

机译：单独和联合番茄红素的维生素E对异丙肾上腺素诱发的大鼠心肌梗死的生化和组织病理学改变的影响

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Background:The present study has been designed to evaluate the combined cardioprotective effect of vitamin E and lycopene on biochemical and histopathological alteration in isoproterenol-induced myocardial infarction in rats.Materials and Methods:Adult male albino rats of Wistar strain were treated with isoproterenol (200 mg/kg, s.c.) for 2 days at an interval of 24 h to develop myocardial infarction. Vitamin E (100 mg/kg/day, p.o.) and lycopene (10 mg/kg/day, p.o.) were administered alone and in combination for 30 days. Change in body weight and organ weight were monitored. Levels of serum marker enzymes (AST, ALT, LDH and CK-MB), lipid peroxidation, endogenous antioxidants (GSH, GPX, GST, SOD and CAT), membrane bound enzymes (Na+/K+ ATPases, Mg2+ ATPases and Ca2+ ATPases) were evaluated. LDH isoenzyme separation was carried out using gel electrophoresis. Histopathology of heart tissue was performed.Results:Induction of rats with isoproterenol resulted in a significant elevation in organ weight, lipid peroxidation, serum marker enzymes (AST, ALT, CK-MB and LDH), and Ca 2+ ATPases, whereas it caused a significant (P < 0.001) decrease in body weight, activities of endogenous antioxidants (GSH, GPx, GST, SOD and CAT), Na+/K+ and Mg2+ ATPases. ISO treated rats showed high intensity band of LDH1-LDH2 isoenzymes. Treatment with the combination of Vitamin E and lycopene for 30 days significantly attenuated these changes as compared to the individual treatment and ISO treated groups. Histopathological observations were also in correlation with the biochemical parameters.Conclusion:These findings indicate the synergistic cardioprotective effects of vitamin E and lycopene during ISO-induced myocardial infarction in rats.
机译：背景：本研究旨在评估维生素E和番茄红素对大鼠异丙肾上腺素引起的心肌梗死的生化和组织病理学改变的联合心脏保护作用。材料与方法：Wistar品系成年雄性白化病大鼠接受异丙肾上腺素（200 mg / kg，皮下注射），每24小时间隔2天，以发展为心肌梗塞。维生素E（100 mg / kg /天，口服）和番茄红素（10 mg / kg /天，口服）单独和组合给药30天。监测体重和器官重量的变化。血清标记酶（AST，ALT，LDH和CK-MB），脂质过氧化，内源性抗氧化剂（GSH，GPX，GST，SOD和CAT）的水平，膜结合酶（Na + / K + ATPase，Mg2 + ATPase和Ca2 + ATPase）的水平为评估。使用凝胶电泳进行LDH同工酶分离。结果：异丙肾上腺素诱导的大鼠器官重量，脂质过氧化，血清标志物酶（AST，ALT，CK-MB和LDH）和Ca 2+ ATPase显着升高，但引起体重，内源性抗氧化剂（GSH，GPx，GST，SOD和CAT），Na + / K +和Mg2 + ATPase的活性显着降低（P <0.001）。经ISO治疗的大鼠显示出高强度的LDH1-LDH2同工酶带。与单独治疗组和ISO治疗组相比，用维生素E和番茄红素联合治疗30天可显着减弱这些变化。组织病理学观察也与生化指标相关。结论：这些发现表明维生素E和番茄红素在ISO诱发的大鼠心肌梗死中具有协同的心脏保护作用。

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