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首页> 外文期刊>Journal of Pharmacopuncture >Calculus Bovis-Fel Uris-Moschus Pharmacopuncture's Effect on Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats
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Calculus Bovis-Fel Uris-Moschus Pharmacopuncture's Effect on Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats

机译：牙结石Bovis-Fel Uris-Moschus药物穿刺对大鼠局部脑血流量和平均动脉血压的影响

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Objectives: This study was designed to investigate the effects of Calculus Bovis-Fel Uris-Moschus pharmacopuncture (BUM) on the regional cerebral blood flow (rCBF) and the mean arterial blood pressure (MABP) in normal and cerebral ischemic rats and to investigate a possible pathway involved in the effects of BUM. Methods: The changes in the rCBF and the MABP following BUM into Fengfu (GV16) were determined by using a laser-Doppler flow meter and a pressure transducer, respectively. Results: BUM significantly increased the rCBF and decreased the MABP in normal rats in a dose-dependent manner. The effect on the rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, intraperitoneal), an inhibitor of guanylate cyclase, but was not affected by pretreatment with indomethacin (1 mg/kg, intraperitoneal), an inhibitor of cyclooxygenase. The BUM-induced decrease of the MABP was changed neither by methylene blue nor by indomethacin pretreatment. In the cerebral ischemic rats, the rCBF was stably increased upon cerebral reperfusion in the BUM group in contrast to the rapid and marked increase in the control group. Conclusion: This study demonstrated that BUM into Fengbu (GV16) increased the rCBF in a dose-dependent manner in the normal state; furthermore, it improved the stability of the rCBF in the ischemic state upon reperfusion. Also, the effects of BUM on the rCBF were attenuated by inhibition of guanylate cyclase, suggesting that the effects involved the guanylate cyclase pathway.
机译：目的：本研究旨在探讨微积分牛肝菌药物（BUM）对正常和脑缺血大鼠局部脑血流量（rCBF）和平均动脉血压（MABP）的影响，并探讨BUM影响的可能途径。方法：采用激光多普勒流量计和压力传感器分别测定BUM进入丰富（GV16）后rCBF和MABP的变化。结果：BUM以剂量依赖性方式显着增加正常大鼠的rCBF并降低MABP。用鸟嘌呤环化酶抑制剂亚甲基蓝（0.01 mg / kg，腹膜内）预处理可显着抑制对rCBF的影响，但用环氧合酶抑制剂吲哚美辛（1 mg / kg，腹膜内）预处理则不会影响rCBF。亚甲基蓝或消炎痛预处理均未改变BUM诱导的MABP降低。在脑缺血大鼠中，BUM组的脑再灌注后，rCBF稳定增加，而对照组则明显增加。结论：这项研究表明，在正常状态下，BUM进入风部（GV16）可增加rCBF，且呈剂量依赖性。此外，它提高了缺血再灌注后rCBF的稳定性。同样，BUM对rCBF的作用被鸟苷酸环化酶的抑制减弱了，表明该作用涉及鸟苷酸环化酶途径。

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