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Parkinson's disease treatments: focus on transcranial direct current stimulation (tDCS)

机译:帕金森氏病的治疗:专注于经颅直流电刺激(tDCS)

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Parkinson’s disease (PD) is among the most common progressive neurodegenerative conditions worldwide, characterized by bradykinesia, rigidity, tremor, and postural instability, in addition to a variety of cognitive and behavior complications. Current pharmacological treatment options focus on dopaminergic replacement, but these become less efficacious as the disease progresses. Noninvasive brain stimulation techniques have therefore gained favor in recent years as a means of treating the motor and non-motor complications of PD. Here we review the evidence behind the use of transcranial direct current stimulation in the treatment of motor and non-motor complications of PD, discuss the limitations that have hindered the introduction of transcranial direct current stimulation into mainstream clinical practice, and highlight future directions that may enable the translation of this research tool into clinical use.
机译:帕金森氏病(PD)是全世界最常见的进行性神经退行性疾病之一,其特征是运动迟缓,僵硬,震颤和姿势不稳,此外还有各种认知和行为并发症。当前的药物治疗选择集中在多巴胺能替代上,但是随着疾病的进展,这些替代药物的疗效降低。因此,近年来,无创性脑刺激技术作为治疗PD的运动和非运动并发症的一种手段而受到青睐。在这里,我们回顾了经颅直流电刺激治疗PD的运动和非运动并发症的背后证据,讨论了阻碍将经颅直流电刺激引入主流临床实践的局限性,并强调了可能的未来方向可以将此研究工具转换为临床用途。

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