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首页> 外文期刊>Journal of Pharmacopuncture >Study on a 4-Week Recovery Test of Sweet Bee Venom after a 13-Week, Repeated, Intramuscular Dose Toxicity Test in Sprague-Dawley Rats
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Study on a 4-Week Recovery Test of Sweet Bee Venom after a 13-Week, Repeated, Intramuscular Dose Toxicity Test in Sprague-Dawley Rats

机译：对Sprague-Dawley大鼠进行13周，重复，肌内剂量毒性试验后的4周甜蜜蜂毒恢复试验的研究

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Objectives: This study was performed to check for reversibility in the changes induced by a 13-week, repeated, dose toxicity test of Sweet Bee Venom (SBV) in Sprague-Dawley (SD) rats. Methods: Fifteen male and 15 female SD rats were treated with 0.28 mg/kg of SBV (high-dosage group) and the same numbers of male and female SD rats were treated with 0.2 mL/kg of normal saline (control group) for 13 weeks. We selected five male and five female SD rats from the high-dosage group and the same numbers of male and female SD rats from the control group, and we observed these rats for four weeks. We conducted body-weight measurements, ophthalmic examinations, urinalyses and hematology, biochemistry, histology tests. Results: (1) Hyperemia and movement disorder were observed in the 13-week, repeated, dose toxicity test, but these symptoms were not observed during the recovery period. (2) The rats in the high-dose group showed no significant changes in weight compared to the control group. (3) No significant differences in the ophthalmic parameters, urine analyses, complete blood cell counts (CBCs), and biochemistry were observed among the recovery groups. (4) No changes in organ weights were observed during the recovery period. (5) Histological examination of the thigh muscle indicated cell infiltration, inflammation, degeneration, necrosis of muscle fiber, and fibrosis during the treatment period, but these changes were not observed during the recovery period. The fatty liver change that was observed during the toxicity test was not observed during the recovery period. No other organ abnormalities were observed. Conclusion: The changes that occurred during the 13-week, repeated, dose toxicity test are reversible, and SBV can be safely used as a treatment modality.
机译：目的：进行这项研究是为了检查在Sprague-Dawley（SD）大鼠中进行的为期13周的重复剂量甜菜毒液（SBV）毒性试验所引起的变化的可逆性。方法：用0.28 mg / kg SBV（高剂量组）治疗15只雄性SD大鼠和15只雌性SD大鼠，用0.2 mL / kg生理盐水（对照组）治疗相同数量的雄性和雌性SD大鼠（对照组）13次周。我们从高剂量组中选择了5只雄性SD大鼠和5只雌性SD大鼠，从对照组中选择了相同数量的雄性SD和雌性SD大鼠，并观察了这些大鼠4周。我们进行了体重测量，眼科检查，尿液分析和血液学，生物化学，组织学测试。结果：（1）在为期13周的重复剂量毒性试验中观察到充血和运动障碍，但在恢复期未观察到这些症状。 （2）大剂量组大鼠体重与对照组相比无明显变化。 （3）恢复组之间的眼科参数，尿液分析，全血细胞计数（CBC）和生化没有显着差异。 （4）恢复期未见器官重量变化。 （5）大腿肌肉的组织学检查显示在治疗期间细胞浸润，炎症，变性，肌纤维坏死和纤维化，但是在恢复期间未观察到这些变化。恢复期未观察到毒性试验中观察到的脂肪肝变化。没有观察到其他器官异常。结论：在13周的重复剂量毒性试验中发生的变化是可逆的，并且SBV可以安全地用作治疗方式。

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