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首页> 外文期刊>Journal of Parkinsonism and Restless Legs Syndrome >Animal models of Parkinson's disease and their applications
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Animal models of Parkinson's disease and their applications

机译：帕金森氏病的动物模型及其应用

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Parkinson's disease (PD) is a progressive neurodegenerative disorder that occurs mainly due to the degeneration of dopaminergic neuronal cells in the substantia nigra. l-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective known therapy for PD. However, chronic L-DOPA administration results in a loss of drug efficacy and irreversible adverse effects, including L-DOPA-induced dyskinesia, affective disorders, and cognitive function disorders. To study the motor and non-motor symptomatic dysfunctions in PD, neurotoxin and genetic animal models of PD have been widely applied. However, these animal models do not exhibit all of the pathophysiological symptoms of PD. Regardless, neurotoxin rat and mouse models of PD have been commonly used in the development of bioactive components from natural herbal medicines. Here, the main animal models of PD and their applications have been introduced in order to aid the development of therapeutic and adjuvant agents.
机译：帕金森氏病（PD）是一种进行性神经退行性疾病，主要是由于黑质中多巴胺能神经元细胞的变性引起的。 1-3，4-二羟基苯丙氨酸（L-DOPA）是已知的最有效的PD疗法。但是，长期服用L-DOPA会导致药物功效丧失和不可逆的不良反应，包括L-DOPA引起的运动障碍，情感障碍和认知功能障碍。为了研究PD的运动和非运动症状功能障碍，PD的神经毒素和遗传动物模型已被广泛应用。但是，这些动物模型没有表现出PD的所有病理生理症状。无论如何，PD的神经毒素大鼠和小鼠模型已普遍用于开发天然草药的生物活性成分。在此，介绍了PD的主要动物模型及其应用，以帮助开发治疗剂和佐剂。

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