...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients
【24h】

Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients

机译：浓度-时间曲线下日本肺移植受者中麦考酚酸及其酰基葡萄糖醛酸苷代谢产物面积的有限采样策略

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: The dose of mycophenolate mofetil (MMF) used to prevent rejection after lung transplantation is often adjusted based on the 12-hour area under the concentration-time curve (AUCsub0-12/sub) of mycophenolic acid (MPA). A limited sampling strategy (LSS) is useful to define the pharmacokinetic (PK) profiles of MPA and mycophenolic acid acyl glucuronide (AcMPAG). Therefore, this study aimed to design a LSS based on multiple linear regression for estimating the AUCsub0-12/sub of MPA and AcMPAG at the minimum blood sampling points in Japanese lung transplant patients with concomitant tacrolimus. Methods: Forty-five lung transplantation recipients were enrolled in a PK study of MPA, mycophenolic acid glucuronide (MPAG), and AcMPAG. The plasma MPA, MPAG, and AcMPAG concentrations were determined just before and at 0.5, 1, 2, 4, 8, and 12 hours after dosing. The AUCsub0-12/sub of MPA and AcMPAG was calculated using a linear trapezoidal rule from the plasma concentration of each blood sampling time. LSS was used to develop models for estimated AUC in the model group (n = 23) and was evaluated in the validation group (n = 22). Results: The best three time-point equation was 4.04 + 1.64·Csub1 /sub+ 3.08·Csub4 /sub+ 5.17·Csub8 /subfor MPA, and -0.13 + 3.01·Csub1 /sub+ 3.51·Csub4 /sub+ 5.74·Csub8/sub for AcMPAG. The prediction errors (PE) and the absolute prediction errors (APE) were within the clinically acceptable ± 5% and 15% range, respectively (MPA: PE = 2.00%, APE = 11.66%, AcMPAG: PE = 0.98%, APE = 14.69%). The percentage of estimated AUCsub0-12/sub within ± 15% of the observed AUCsub0-12/sub was 77.27% for MPA and 81.82% for AcMPAG. Conclusion: LSS using three time-point (Csub1/sub, Csub4/sub, and Csub8/sub) provides the most reliable and accurate simultaneous estimation of the AUCsub0-12 /subof MPA and AcMPAG in Japanese lung transplant patients.
机译：目的：经常根据霉酚酸（-）的浓度-时间曲线（AUC 0-12 ）下的12小时面积来调整用于预防肺移植后排斥反应的霉酚酸酯（MMF）的剂量。 MPA）。有限采样策略（LSS）可用于定义MPA和麦考酚酸酰基葡糖醛酸（AcMPAG）的药代动力学（PK）谱。因此，本研究旨在设计一种基于多元线性回归的最小二乘法，用于估计日本他克莫司并发肺移植患者最低采血点的MPA和AcMPAG的AUC 0-12 。方法：45位肺移植受者参加了MPA，麦考酚酸葡糖醛酸（MPAG）和AcMPAG的PK研究。在给药前和给药后0.5、1、2、4、8和12小时测定血浆MPA，MPAG和AcMPAG的浓度。 MPA和AcMPAG的AUC 0-12 使用线性梯形法则由每个血液采样时间的血浆浓度计算得出。 LSS用于在模型组（n = 23）中开发用于估计的AUC的模型，并在验证组（n = 22）中进行评估。结果：MPA的最佳三个时间点方程为4.04 + 1.64·C 1 + 3.08·C 4 + 5.17·C 8 ，和-0.13 + 3.01·C 1 + 3.51·C 4 + 5.74·C 8 。预测误差（PE）和绝对预测误差（APE）分别在临床可接受的±5％和15％范围内（MPA：PE = 2.00％，APE = 11.66％，AcMPAG：PE = 0.98％，APE = 14.69％）。在估计的AUC 0-12 的±15％内，估计的AUC 0-12 的百分比对于MPA是77.27％，对于AcMPAG是81.82％。结论：使用三个时间点（C 1 ，C 4 和C 8 ）的LSS提供了最可靠，最准确的同时估计日本肺移植患者MPA和AcMPAG的AUC 0-12

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号