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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Antidepressant Use and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis
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Antidepressant Use and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis

机译：抗抑郁药的使用和静脉血栓栓塞症的风险：系统评价和荟萃分析

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Abstract Purpose. Studies provided conflicting results on whether antidepressant use increased the risk of venous thromboembolism (VTE). Our aim was to examine the association between antidepressant use and the risk of VTE. Methods. Pubmed, Embase, and the Cochrane Library were searched up to March 13, 2018. Case-control studies and cohort studies that examined the association between antidepressant use and the risk of VTE, deep vein thrombosis or pulmonary embolism were included. Several subgroup analyses and sensitivity analyses were conducted. GRADE approach was used to assess the quality of evidence. Results. Nine studies (six case-control studies and three cohort studies) were included. Overall, antidepressant use may be associated with an increased risk of VTE (OR 1.27, 95% CI 1.09 to 1.49); however, no association was observed in studies with low risk of bias (OR 1.27, 95% CI 0.84 to 1.92). No association between selective serotonin reuptake inhibitor use and VTE risk was detected in the overall analysis (OR 1.10, 95% CI 0.90 to 1.34) and in subgroup analysis of studies with low risk of bias. Tricyclic antidepressant may be associated with an increased VTE risk (OR 1.26, 95% CI 1.02 to 1.57), and the quality of evidence was rated as very low by GRADE approach; however, no association was observed when we only included studies with low risk of bias. Conclusions. There was no association between selective serotonin reuptake inhibitor use and VTE risk. Tricyclic antidepressant may be associated with an increased VTE risk, but the quality of evidence was very low.
机译：抽象目的。关于抗抑郁药的使用是否会增加静脉血栓栓塞（VTE）的风险，研究提供了相互矛盾的结果。我们的目的是研究抗抑郁药与VTE风险之间的关系。方法。检索截至2018年3月13日的Pubmed，Embase和Cochrane库。包括病例对照研究和队列研究，这些研究检查了抗抑郁药使用与VTE，深静脉血栓形成或肺栓塞风险之间的关系。进行了几个亚组分析和敏感性分析。 GRADE方法用于评估证据的质量。结果。包括九项研究（六项病例对照研究和三项队列研究）。总体而言，抗抑郁药的使用可能会增加VTE的风险（OR 1.27，95％CI 1.09至1.49）;但是，在偏倚风险低的研究中未观察到关联（OR 1.27，95％CI 0.84至1.92）。在总体分析（OR 1.10，95％CI 0.90至1.34）和偏倚风险低的研究的亚组分析中，未发现选择性5-羟色胺再摄取抑制剂的使用与VTE风险之间存在关联。三环类抗抑郁药可能与增加的VTE风险有关（OR 1.26，95％CI 1.02至1.57），证据质量被GRADE方法评为非常低。但是，当我们仅纳入偏倚风险较低的研究时，则未观察到关联。结论。选择性5-羟色胺再摄取抑制剂的使用与VTE风险之间没有关联。三环类抗抑郁药可能与增加的VTE风险有关，但证据质量很低。

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