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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >The Role of Xenobiotic Transporters in Ophthalmic Drug Delivery
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The Role of Xenobiotic Transporters in Ophthalmic Drug Delivery

机译：异种生物转运蛋白在眼科药物传递中的作用

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摘要

The eye is a very complex sensory organ consisting of numerous structures to coordinate the function of sight. It has a series of physical and chemical barriers to help maintain its homeostasis, and mediate environmental exposures. Transporters in the eye play a very important role in maintaining homeostasis by facilitating the movement of ions, nutrients and xenobiotics to various tissues in the eye, especially to non-vascular tissues like the lens and cornea. They also ensure proper cell signaling by shuttling neurotransmitters within the retina. Thus, they are expected to play an important role in determining the ocular exposure of drugs and other pharmacotherapeutics. However, the role of ocular transporters in ophthalmic drug delivery and their clinical relevance has not been well characterized. The purpose of the present review is to summarize the current evidence in the literature on ocular drug transporters and their role in ocular drug delivery, with the emphasis predominantly on their role in ocular pharmacokinetics. This article is open to POST-PUBLICATION REVIEW . Registered readers (see "For Readers") may comment by clicking on on the issue's contents page.
机译：眼睛是非常复杂的感觉器官，由许多结构组成，以协调视觉功能。它具有一系列物理和化学屏障，可帮助维持体内稳态，并介导环境暴露。眼中的转运蛋白通过促进离子，营养素和异种生物素向眼内各种组织的运动，尤其是向晶状体和角膜等非血管组织的运动，在维持体内平衡方面起着非常重要的作用。它们还通过在视网膜内穿梭神经递质来确保适当的细胞信号传导。因此，预期它们在确定药物和其他药物治疗剂的眼部暴露中将发挥重要作用。然而，眼转运蛋白在眼科药物递送中的作用及其临床相关性尚未得到很好的表征。本综述的目的是总结有关眼用药物转运蛋白及其在眼用药物递送中作用的文献中的当前证据，重点是它们在眼药代动力学中的作用。本文对POST-PUBLICATION REVIEW开放。注册的读者（请参阅“针对读者”）可以通过单击问题的内容页面来发表评论。

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