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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Quantification of Three Chiral Flavonoids with Reported Bioactivity in Selected Licensed Canadian Natural Health Products and US Marketed Dietary Supplements
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Quantification of Three Chiral Flavonoids with Reported Bioactivity in Selected Licensed Canadian Natural Health Products and US Marketed Dietary Supplements

机译：在选定的加拿大许可天然保健产品和美国市场上销售的膳食补充剂中，对三种具有报告的生物活性的手性黄酮进行定量分析

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Purpose. Research indicating potentially beneficial bioactivity of flavonoids has produced a market and demand for natural health products and dietary supplements containing flavonoids. Implementation of the Canadian natural health product (NHP) regulations in January of 2004 increased regulation and oversight of NHP manufacture and marketing leading many consumers and clinicians to assume a similar pathway of development and approval to over-the-counter or prescription drugs. Methods. Three stereospecific liquid chromatograph/mass spectrometry (LC/MS) methods were used to assess the flavonoids, liquiritigenin, pinocembrin, and pinostrobin, in selected Canadian licensed NHP’s and US marketed dietary supplements. Results. The present study quantifies bioactive flavonoids in these products and notes variability in flavonoid content. Conclusions. Efficacy and safety of NHP’s and dietary supplements should not be assumed due to differences in criteria for NHP licensure by Health Canada as well as variation of flavonoid content between manufacturers and products with similar indications for use. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on on the issue’s contents page.
机译：目的。研究表明类黄酮具有潜在的有益生物活性，因此对天然保健产品和含有类黄酮的膳食补充剂产生了市场和需求。 2004年1月实施的加拿大天然保健产品（NHP）法规加强了对NHP生产和销售的法规和监管，导致许多消费者和临床医生采用类似的开发和批准非处方药或处方药的途径。方法。三种立体定向液相色谱/质谱法（LC / MS）用于评估选定的加拿大许可的NHP和美国销售的膳食补充剂中的类黄酮，liquiritigenin，pinocembrin和pinostrobin。结果。本研究定量了这些产品中的生物活性类黄酮，并指出了类黄酮含量的变化。结论。由于加拿大卫生部对NHP的许可标准不同以及制造商和使用类似适应症的产品之间的类黄酮含量存在差异，因此不应假定NHP和膳食补充剂的功效和安全性。本文对发布后审查开放。已注册的读者（请参阅“针对读者”）可以通过单击问题的内容页面来发表评论。

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