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首页> 外文期刊>Journal of Proteins and Proteomics >CARBON DISTRIBUTION IN PROTEIN LOCAL STRUCTURE DIRECT SUPEROXIDE DISMUTASE TO DISEASE WAY
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CARBON DISTRIBUTION IN PROTEIN LOCAL STRUCTURE DIRECT SUPEROXIDE DISMUTASE TO DISEASE WAY

机译：蛋白质局部结构中直接过氧化物歧化病的碳分布

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During the reaction involving superoxide dismutase (SOD), the oxidized Cu(II) form converts one superoxide molecule into oxygen while itself getting reduced to Cu(I) form. This reduced form of Cu(I) again converts another superoxide molecule into hydrogen peroxide and returns to oxidized Cu(II) form. Amyotrophic sclerosis is associated to instability in SOD and oxidative damage. Amyotrophic sclerosis mutants of human SOD form aggregates due to destabilization. Mostly these aggregates are due to hydrophobic interaction which comes from carbon present in the SOD. Some of these mutations found in amyotrophic sclerosis are studied here. Results reveal that most of these mutations alter local hydrophobic structures that are responsible for disorder. Carbon distribution analysis program is effective in identification and modification of mutational sites in biological sequences. This can be better exploited for gene therapy.
机译：在涉及超氧化物歧化酶（SOD）的反应过程中，氧化的Cu（II）形式将一个超氧化物分子转化为氧，而其本身又还原为Cu（I）形式。这种还原形式的Cu（I）再次将另一个超氧化物分子转化为过氧化氢，并返回为氧化的Cu（II）形式。肌萎缩性硬化症与SOD不稳定和氧化损伤有关。人类SOD的肌萎缩性硬化症突变体由于不稳定而形成聚集体。大多数情况下，这些聚集体是由于疏水性相互作用而产生的，该疏水性来自SOD中存在的碳。在这里研究了肌萎缩性硬化症中发现的某些突变。结果显示，这些突变大多数会改变导致疾病的局部疏水结构。碳分布分析程序可有效识别和修饰生物序列中的突变位点。这可以更好地用于基因治疗。

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