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首页> 外文期刊>Journal of Rehabilitation Research and Development >Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis
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Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis

机译：极低频磁场在预防脊髓损伤引起的骨质疏松症中的作用

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The present study was designed to investigate the effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)induced osteoporosis in rats. Adult male Wistar rats (n = 24) were equally divided into sham, SCI, and SCI+MF groups. Complete transection of spinal cord (thoracic 11 vertebra) was surgically performed under anesthesia, whereas in the sham group only laminectomy was done. PostSCI day 1, rats were either exposed (2 h/d × 8 wk) to ELFMF (17.96 microTesla, 50 Hz; SCI+MF group) or sham exposed (SCI group). Basso, Beattie, and Bresnahan (BBB) score was recorded weekly. All the rats were sacrificed 8 wk postSCI; tibia and femur bones were isolated for the analysis of bone mineral content (BMC; total calcium [Ca], phosphorus [P], carbon [C]), bone mineral density (BMD), and biochemical status (osteocalcin, collagen I, alkaline phosphatase). The BBB score decreased postSCI, which partially recovered after ELFMF. In SCI rats, there was a statistically significant decrease in BMC, Ca, P, C, BMD, and biochemical level in both the bones as compared with the sham group, which was attenuated in SCI+MF rats except the C content. Electron microscopic study revealed the enhancement of microstructural composition and compactness in cortical and trabecular parts of treated bones. The results suggest that the chronic (2 h/d × 8 wk) ELFMF exposure (17.96 microTesla, 50 Hz) to SCI rats is effective in attenuating SCIinduced osteoporosis.
机译：本研究旨在研究极低频（ELF）磁场（MF）对大鼠脊髓损伤（SCI）引起的骨质疏松的影响。将成年雄性Wistar大鼠（n = 24）分为假，SCI和SCI + MF组。在麻醉下通过外科手术完全切除脊髓（胸椎11椎），而假手术组仅进行椎板切除术。 SCI第1天后，将大鼠暴露于ELFMF（17.96 microTesla，50 Hz; SCI + MF组）（2 h / d×8 wk）或进行假手术（SCI组）。每周记录Basso，Beattie和Bresnahan（BBB）得分。 SCI后8周将所有大鼠处死。分离胫骨和股骨，以分析骨矿物质含量（BMC;总钙[Ca]，磷[P]，碳[C]），骨矿物质密度（BMD）和生化状态（骨钙蛋白，胶原蛋白I，碱性）磷酸酶）。 SCI后BBB评分降低，ELFMF后部分恢复。与假手术组相比，在SCI大鼠中，两块骨头的BMC，Ca，P，C，BMD和生化水平均有统计学意义的降低，除C含量外，在SCI + MF大鼠中均降低。电子显微镜研究显示，经治疗的骨骼的皮质和小梁部分的显微结构组成和致密性得到增强。结果表明，SCI大鼠长期（2 h / d×8 wk）ELFMF暴露（17.96 microTesla，50 Hz）可有效减轻SCI引起的骨质疏松。

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