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首页> 外文期刊>Journal of Rural and Remote Environmental Health >PREVALENCE OF DUFFY BLOOD GROUPS AMONG THE POPULATION OF THE DESERT REGION OF INDIA
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PREVALENCE OF DUFFY BLOOD GROUPS AMONG THE POPULATION OF THE DESERT REGION OF INDIA

机译：印度沙漠地区人口中的傻瓜血统流行率

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ABSTRACT Objectives: The distribution of vivax malaria is uneven in India and Plasmodium vivax is predominant in the North-Western part. Distribution of Duffy blood groups and its prevalence are important for regions where P. vivax predominates, because this molecule on the surface of the red blood cell acts as a receptor for P. vivax. The tribal (aboriginal) and desert area of the state Rajasthan contributes 70% to the malaria disease burden. The study was undertaken to identify the Duffy phenotypes present in the Rajasthan population and their prevalence. Methods: The study population was divided in to tribal and non-tribal groups and into healthy and P. vivax malaria infected groups. Duffy blood groupings of 96 unrelated subjects were carried out by the indirect antiglobulin technique. Simultaneously, malaria status was assessed for all participants using peripheral blood. Results: In the tribal population the prevalence of Duffy phenotypes Fy(a+b-), Fy(a-b+) and Fy(a+b+) were 18.5%, 11.1% and 70.4%, respectively. The prevalence of Duffy phenotype Fy(a+b+) was 15.6% lower in the non-tribal population. The percentage of both tribal and non-tribal population with Duffy phenotype Fy(a+b+) were significantly (p<0.001) higher than the population with Duffy phenotype Fy(a+b-) and Fy(a-b+). The Duffy phenotype Fy(a-b-) was absent in the population of the desert region. A higher prevalence of Duffy phenotype Fy(a+b+) was recorded for malaria patients (83.3%) than for healthy participants (59.0%). Conclusions: The population of the North-Western part of India was susceptible for P. vivax malaria infection and the tribal population seemed to be more susceptible than the non-tribal population.
机译：摘要目标：印度的间日疟原虫分布不均，西北部以间日疟原虫为主。 Duffy血型的分布及其流行率对于间日疟原虫占主导地位的地区很重要，因为红细胞表面的该分子充当间日疟原虫的受体。拉贾斯坦邦的部落（原始）和沙漠地区造成了70％的疟疾负担。进行该研究以鉴定存在于拉贾斯坦人口中的达菲表型及其患病率。方法：将研究人群分为部落和非部落人群，以及健康人群和间日疟原虫疟疾感染人群。通过间接抗球蛋白技术对96位无关受试者的达菲血型进行了分组。同时，使用外周血对所有参与者的疟疾状况进行了评估。结果：在部落人口中，达菲表型Fy（a + b-），Fy（a-b +）和Fy（a + b +）的患病率分别为18.5％，11.1％和70.4％。在非部落人群中，达菲表型Fy（a + b +）的患病率低15.6％。达菲表型为Fy（a + b +）的部落和非部落人口百分比均显着（p <0.001），高于达菲表型为Fy（a + b-）和Fy（a-b +）的人口。在沙漠地区的人口中没有达菲表型Fy（a-b-）。疟疾患者（83.3％）的Duffy表型Fy（a + b +）患病率高于健康参与者（59.0％）。结论：印度西北部地区的人群易感间日疟原虫疟疾，部落人群似乎比非部落人群更易感染。

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