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首页> 外文期刊>Journal of Research in Dental Sciences >Evaluating the Quality of Life in Patients with Oral Squamous Cell Carcinoma and the Associated Factors in those Referring to Imam Khomeini Cancer Institute, 2012
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Evaluating the Quality of Life in Patients with Oral Squamous Cell Carcinoma and the Associated Factors in those Referring to Imam Khomeini Cancer Institute, 2012

机译：评估口腔鳞状细胞癌患者的生活质量及其相关因素，参见伊玛目霍梅尼癌症研究所，2012年

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ABSTRACTBackground and Aim: Various kinds of cancer can negatively affect the quality of life in patients and can indirectly affect the therapeutic results. The current study was enrolled to assess the quality of life in patients with oral squamous cell carcinoma and identify the associated factors to be used for improving the quality of life in patients. This was done on patients referring to Imam Khomeini Cancer Institute, 2012-13. Materials and Methods: In this descriptive research, 100 patients with OSCC were enrolled 3 months after the end of diagnostic and therapeutic stages when they were in follow-up stage. They were interviewed using EORTC QLQ- H&N35 questionnaire which its validity and reliability was affirmed by Cronbach’s α=0.858. The questionnaire consisted of 35 questions concerning 8 indices (pain, swallowing status, sense of taste, speech,feeling of malaise, social communication, eating in public and sexual desire). At the same time, patients were interviewed and the clinico-demographic characteristics form was completed for each of them. Then, the relation between these indices of quality of life and the studied variables was assessed using Mann-Whitney U-test and Kruskal-Wallis test.Results: As the stage of illness advanced, the quality of life declined in most factors (P0.05). Women were found to have lower quality of life than men regarding swallowing status, pain, and feeling of malaise (P=0.01). The patients who had OSCC on tongue, lips and buccal mucosa had lower quality of life in terms of swallowing and speaking (P=0.004 and 0.005, respectively). The type of treatment affected the indices of swallowing and feeling of malaise. (P=0.04 and 0.007, respectively).Conclusion: It seems that the site of tumor and the type of treatment play role in reducing the quality of life of patients with OSCC but advancement in stage of illness was found to be the most important index in decreasing the quality of life.
机译：摘要背景与目的：各种癌症都可能对患者的生活质量产生负面影响，并间接影响治疗效果。本研究被纳入评估口腔鳞状细胞癌患者的生活质量，并确定可用于改善患者生活质量的相关因素。这项工作是针对2012-13年度伊玛目霍梅尼癌症研究所的患者进行的。资料和方法：在这项描述性研究中，100例OSCC患者在诊断和治疗阶段结束后3个月进入随访阶段。他们使用EORTC QLQ-H＆N35问卷进行了访谈，其问卷的有效性和可靠性得到了Cronbach的== 0.858的肯定。问卷包括35个问题，涉及8个指标（疼痛，吞咽状态，味觉，言语，不适感，社会交往，在公共场合进食和性欲）。同时，对患者进行了访谈，并为他们完成了每个人的临床人口统计学特征表。然后，使用Mann-Whitney U检验和Kruskal-Wallis检验评估了这些生活质量指标与研究变量之间的关系。结果：随着疾病的发展，大多数因素下的生活质量下降（P < 0.05）。在吞咽状态，疼痛和不适感方面，发现女性的生活质量比男性低（P = 0.01）。在吞咽和说话方面，OSCC患者的舌头，嘴唇和颊粘膜OSCC生活质量较低（分别为P = 0.004和0.005）。治疗的类型影响吞咽和不适感的指标。 （分别为P = 0.04和0.007）。结论：似乎肿瘤部位和治疗类型在降低OSCC患者的生活质量中起着作用，但发现疾病的进展是最重要的指标降低生活质量

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