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首页> 外文期刊>Journal of structural and functional genomics >The crystal structure of Rv0793, a hypothetical monooxygenasefrom M.?tuberculosis
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The crystal structure of Rv0793, a hypothetical monooxygenasefrom M.?tuberculosis

机译：Rv0793的晶体结构，一种结核分枝杆菌的假定单加氧酶

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Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6?? resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.
机译：结核分枝杆菌感染全球数百万人。结核分枝杆菌的结构基因组学联盟已将这种细菌的所有基因作为目标，希望发现和开发新的治疗剂。结核分枝杆菌的开放阅读框Rv0793带有未知功能。 Rv0793的3维结构已解决为1.6 ??解析度。它的结构与天蓝色链霉菌ActVA-Orf6非常相似，后者是一种单加氧酶，在缺乏辅因子的情况下参与聚酮化合物抗生素的定制。它也类似于最近解析的YgiN的结构，YgiN是一种来自大肠杆菌的喹诺酮单加氧酶。此外，Rv0793的结构类似于功能未知的其他蛋白质的几种结构。由于各种细菌物种的结构基因组计划，最近已确定了这些后面的结构。在结核分枝杆菌中，Rv0793及其同源物可能代表一类单氧合酶，它们充当活性氧清除剂，对于逃避宿主防御至关重要。由于宿主防御对结核分枝杆菌的最普遍的攻击方式是活性氧和活性氮，因此Rv0793可能为抵抗结核分枝杆菌的感染提供了新的靶标。

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