Localized laryngeal amyloidosis is a rare disease with poorly understood aetiology. The commonest symptom at presentation is dysphonia and for a correct diagnosis of amyloidosis to be made a high index of suspicion is needed [Fraihat A, Ardah A. Laryngeal amyloidosis: a case report. J R Med Serv 2005;17:57–9; Passerotti GH, Caniello M, Hachiya A, Santoro PP, Imamura R, Tsuji DH. Multiple sited amyloidosis in the upper aerodigestive tract: case report and literature review. Rev Bras Otorrinolaringol 2008;74:462–6]. We present a case of a 48-year-old male who was investigated over a 5-year period for persistent and progressive hoarseness of voice before the accurate diagnosis of localized amyloidosis was reached. Management of this case consisted of local treatment with endoscopic carbon dioxide laser excision of laryngeal lesions to good effect and exclusion of systemic disease with yearly follow-up for monitoring disease progression.
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机译：局部性喉淀粉样变性病是一种罕见病，其病因学知之甚少。表现上最常见的症状是声音障碍，为了正确诊断淀粉样变性，需要高度怀疑[Fraihat A，Ardah A.喉淀粉样变性：病例报告。 J R Med Serv 2005; 17：57–9; Passerotti GH，Caniello M，Hachiya A，Santoro PP，Imamura R，Tsuji DH。上消化道多部位淀粉样变性病：病例报告和文献复习。 Rev Bras Otorrinolaringol 2008; 74：462-6]。我们提供了一个案例，该案例为48岁的男性，经过5年的研究，他们在持续准确诊断局部淀粉样变性之前，对声音的持续性和进行性声音嘶哑进行了调查。该病例的治疗包括用内镜下二氧化碳激光切除喉部病变以取得良好效果的局部治疗，并排除全身疾病，并每年进行随访以监测疾病的进展。
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