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首页> 外文期刊>Journal of Surgical Case Reports >Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor
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Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor

机译：5岁双侧Wilms肿瘤患儿的肿瘤延迟切除

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We describe the case of a 5-year-old girl whose abdominal pain and distension were caused by Wilms tumor of the kidney. Because of the bilateral nature of her disease, she was spared biopsy or initial nephrectomy as part of her treatment course. Rather, she was treated presumptively for Wilms tumor based primarily on radiologic findings. Neoadjuvant chemotherapy consisting of vincristine, dactinomycin and doxorubicin was given to facilitate nephron-sparing surgery for tumor resection. Her initial chemotherapeutic course was complicated by tumor lysis syndrome manifested by elevated serum uric acid and was treated effectively with hyperhydration and alkalization of intravenous fluids. The patient's disease responded well to chemotherapy, and she underwent successful tumor excision after 12 weeks of chemotherapy. The resected tumor was identified as anaplastic Wilms tumor, illustrating that pathologic identification of Wilms tumor is possible even after multiple cycles of neoadjuvant chemotherapy and marked tumor shrinkage.
机译：我们描述了一个5岁女孩的案例，该女孩的腹痛和腹胀是由肾脏的Wilms肿瘤引起的。由于她的疾病是双侧性的，因此在治疗过程中不做活检或初次肾切除术。相反，主要根据放射学发现对她进行了威尔姆斯肿瘤的推测治疗。给予了由长春新碱，放线菌素和阿霉素组成的新辅助化疗，以促进保留肾单位的肿瘤切除手术。她最初的化疗过程是由血清尿酸升高引起的肿瘤溶解综合症所致，并通过静脉水合液的过度水化和碱化得到了有效治疗。病人的疾病对化疗反应良好，化疗12周后，她成功地切除了肿瘤。切除的肿瘤被鉴定为间变性Wilms肿瘤，这说明即使在新辅助化疗的多个周期和明显的肿瘤缩小后，Wilms肿瘤的病理学鉴定也是可能的。

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