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The eightfold path to non-enzymatic RNA replication

机译：非酶RNA复制的八重途径

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The first RNA World models were based on the concept of an RNA replicase - a ribozyme that was a good enough RNA polymerase that it could catalyze its own replication. Although several RNA polymerase ribozymes have been evolved in vitro , the creation of a true replicase remains a great experimental challenge. At first glance the alternative, in which RNA replication is driven purely by chemical and physical processes, seems even more challenging, given that so many unsolved problems appear to stand in the way of repeated cycles of non-enzymatic RNA replication. Nevertheless the idea of non-enzymatic RNA replication is attractive, because it implies that the first heritable functional RNA need not have improved replication, but could have been a metabolic ribozyme or structural RNA that conferred any function that enhanced protocell reproduction or survival. In this review, I discuss recent findings that suggest that chemically driven RNA replication may not be completely impossible.
机译：最早的RNA World模型基于RNA复制酶的概念-一种核酶，它是一种足够好的RNA聚合酶，可以催化自身复制。尽管体外已经进化出几种RNA聚合酶核酶，但创建真正的复制酶仍然是巨大的实验挑战。乍看之下，考虑到这么多未解决的问题似乎阻碍了非酶RNA复制的重复循环，纯粹由化学和物理过程驱动RNA复制的替代方案似乎更具挑战性。然而，非酶RNA复制的想法很有吸引力，因为它暗示着第一个可遗传的功能RNA不需要改善复制，而可能是代谢核酶或结构RNA，它们赋予了任何增强原细胞繁殖或存活的功能。在这篇综述中，我讨论了最近的发现，这些发现表明化学驱动的RNA复制可能并非完全不可能。

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