Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria-Targeting Cytoprotective Peptide

Alan P. Kypson; Chad R. Frasier; Corinne A. Watson; David A. Brown; Joseph H. Gorman; Kevin J. Koomalsingh; Phillip A. Bostian; Robert A. Kloner; Robert C. Gorman; Ruben C. Sloan; Sharon L. Hale; Takashi Shuto; Wangde Dai

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Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria-Targeting Cytoprotective Peptide

机译：使用线粒体靶向细胞保护肽Bendavia减少局部缺血/再灌注损伤

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Background Manifestations of reperfusion injury include myocyte death leading to infarction, contractile dysfunction, and vascular injury characterized by the “no-reflow” phenomenon. Mitochondria-produced reactive oxygen species are believed to be centrally involved in each of these aspects of reperfusion injury, although currently no therapies reduce reperfusion injury by targeting mitochondria specifically.

机译：背景技术再灌注损伤的表现包括导致梗死的心肌细胞死亡，收缩功能障碍和以“无回流”现象为特征的血管损伤。线粒体产生的活性氧被认为与再灌注损伤的各个方面都有关，尽管目前尚无疗法通过特异性靶向线粒体来减轻再灌注损伤。

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《Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease》 |2012年第3期|共页
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Alan P. Kypson; Chad R. Frasier; Corinne A. Watson; David A. Brown; Joseph H. Gorman; Kevin J. Koomalsingh; Phillip A. Bostian; Robert A. Kloner; Robert C. Gorman; Ruben C. Sloan; Sharon L. Hale; Takashi Shuto; Wangde Dai;
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中图分类临床医学;
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1. Reduction of early reperfusion injury with the mitochondria-targeting peptide Bendavia [J] . BrownD.A., HaleS.L., BainesC.P., Journal of cardiovascular pharmacology and therapeutics . 2014,第1期

机译：线粒体靶向肽Bendavia减少早期再灌注损伤
2. CYTOPROTECTIVE ACTION OF SOLUBLE HEME OXYGENASE-1-CELL PENETRATING PEPTIDE (SHO-1-CPP) OBSERVED IN IN VITRO HEPATIC ISCHEMIA-REPERFUSION INJURY (IRI) MODELS [J] . Venkatachalam A., Ray A., Maclean J., Transplant international : . 2016,第Suppla2期

机译：在体外肝缺血再灌注损伤（IRI）模型中观察到的可溶性血红素氧合酶-1细胞穿透肽（SHO-1-CPP）的细胞保护作用
3. Cytoprotective effects of a cyclic RGD peptide in steatotic liver cold ischemia and reperfusion injury. [J] . Fondevila C, Shen XD, Duarte S, American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . 2009,第10期

机译：环状RGD肽在脂肪变性肝冷缺血和再灌注损伤中的细胞保护作用。
4. Comparison of the Effects of Myristoylated and Transactivating Peptide (TAT) Conjugated Mitochondrial Fission Peptide Inhibitor (P110) in Myocardial Ischemia/Reperfusion (I/R) Injury [C] . Israel Benjamin, Jonathan Vu, Christina Lipscombe American Peptide Symposium . 2015

机译：MyRistoyaated肽（TAT）缀合的线粒体裂变肽抑制剂（P110）在心肌缺血/再灌注（I / R）损伤中的损伤效果比较
5. Mechanisms of NK cell-mediated injury in ischemia reperfusion injury in the kidney [D] . Ramirez-Victorino, Francisco 2015

机译：NK细胞介导的肾脏缺血再灌注损伤机制
6. Reduction of Ischemia/Reperfusion Injury With Bendavia a Mitochondria-Targeting Cytoprotective Peptide [O] . Robert A. Kloner, Sharon L. Hale, Wangde Dai, 2012

机译：使用线粒体靶向细胞保护肽Bendavia减少局部缺血/再灌注损伤
7. Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria-Targeting Cytoprotective Peptide [O] . Kloner, Robert A., Hale, Sharon L., Dai, Wangde, 2012

机译：使用线粒体靶向细胞保护肽Bendavia减少局部缺血/再灌注损伤

Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria-Targeting Cytoprotective Peptide

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