首页> 外文期刊>Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease >Calcium/Calmodulin‐Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II–Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function
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Calcium/Calmodulin‐Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II–Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function

机译:钙/钙调蛋白依赖性激酶II抑制平滑肌可通过控制主动脉重构和压力感受器功能减少血管紧张素II诱导的高血压。

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摘要

Background Multifunctional calcium/calmodulin‐dependent kinase II (CaMKII) is activated by angiotensin II (Ang II) in cultured vascular smooth muscle cells (VSMCs), but its function in experimental hypertension has not been explored. The aim of this study was to determine the impact of CaMKII inhibition selectively in VSMCs on Ang II hypertension.
机译:背景多功能钙/钙调蛋白依赖性激酶II(CaMKII)在培养的血管平滑肌细胞(VSMC)中被血管紧张素II(Ang II)激活,但尚未探索其在实验性高血压中的功能。这项研究的目的是确定VSMC中CaMKII选择性抑制对Ang II高血压的影响。

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