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首页> 外文期刊>Journal of the Brazilian Chemical Society >Determination of vitamin B6 (pyridoxine) in pharmaceutical preparations by cyclic voltammetry at a copper(II) hexacyanoferrate(III) modified carbon paste electrode
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Determination of vitamin B6 (pyridoxine) in pharmaceutical preparations by cyclic voltammetry at a copper(II) hexacyanoferrate(III) modified carbon paste electrode

机译:六氰合铁酸铜(III)修饰碳糊电极上的循环伏安法测定药物制剂中的维生素B6(吡rid醇)

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A copper(II) hexacyanoferrate(III) (CuHCF) modified carbon paste electrode was used for the electroanalytical determination of pyridoxine (vitamin B6) in pharmaceutical preparations, using cyclic voltammetry. Diverse parameters were investigated for the optimization of the sensor response, such as composition of the electrode, electrolytic solution, effect of pH, scan rate of potential and interferences. The optimum conditions were found at an electrode composition of 20% CuHCF, 55% graphite and 25% mineral oil (m/m) in an acetate buffer (pH 5.5) containing 0.05 mol L-1 of NaCl. The range of determination of pyridoxine was from 1.2 x 10-6 to 6.9 x 10-4 mol L-1. The procedure was successfully applied to the determination of vitamin B6 in formulation preparations. The CuHCF modified carbon paste electrode gave results comparable to those obtained using spectrophotometry.
机译:使用循环伏安法,将六氰基铁酸铜(II)(III)(CuHCF)修饰的碳糊电极用于电分析测定药物制剂中的吡ido醇(维生素B6)。研究了用于优化传感器响应的各种参数,例如电极的成分,电解液,pH值的影响,电势的扫描速率和干扰。在包含0.05 mol L-1的NaCl的醋酸盐缓冲液(pH 5.5)中,电极成分为20%CuHCF,55%石墨和25%矿物油(m / m)时,发现了最佳条件。吡ido醇的测定范围为1.2×10-6至6.9×10-4mol L-1。该方法已成功应用于制剂制剂中维生素B6的测定。 CuHCF修饰的碳糊电极的结果可与使用分光光度法获得的结果相媲美。

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