Tumor Necrosis Factor–Related Apoptosis‐Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia‐Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide–Dependent Mechanisms

Amanda Wing Shee Yeung; Belinda Ann Di Bartolo; Carmine Gentile; Jayant Ravindran; Leonel Prado‐Lourenco; Mary Meltem Kavurma; Nor Saadah Muhammad Azahri; Shane Ross Thomas; Sian Peta Cartland; Thomas Scott Griffith; Thuan Thai

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Tumor Necrosis Factor–Related Apoptosis‐Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia‐Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide–Dependent Mechanisms

机译：肿瘤坏死因子相关的凋亡诱导配体（TRAIL）通过NADPH氧化酶4（NOX4）和一氧化氮依赖性机制促进血管生成和缺血诱导的新血管形成。

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Background Tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL) has the ability to inhibit angiogenesis by inducing endothelial cell death, as well as being able to promote pro‐angiogenic activity in vitro. These seemingly opposite effects make its role in ischemic disease unclear. Using Trail?/? and wildtype mice, we sought to determine the role of TRAIL in angiogenesis and neovascularization following hindlimb ischemia.

机译：背景肿瘤坏死因子相关的凋亡诱导配体（TRAIL）具有通过诱导内皮细胞死亡来抑制血管生成的能力，并能够在体外促进促血管生成活性。这些看似相反的作用尚不清楚其在缺血性疾病中的作用。使用Trail ？/？和野生型小鼠，我们试图确定TRAIL在后肢缺血后在血管生成和新血管形成中的作用。

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《Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease》 |2015年第3期|共页
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Amanda Wing Shee Yeung; Belinda Ann Di Bartolo; Carmine Gentile; Jayant Ravindran; Leonel Prado‐Lourenco; Mary Meltem Kavurma; Nor Saadah Muhammad Azahri; Shane Ross Thomas; Sian Peta Cartland; Thomas Scott Griffith; Thuan Thai;
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1. Tumor Necrosis Factor–Related Apoptosis‐Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia‐Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide–Dependent Mechanisms [J] . Amanda Wing Shee Yeung, Belinda Ann Di Bartolo, Carmine Gentile, Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease . 2015,第1期

机译：肿瘤坏死因子相关的凋亡诱导配体（TRAIL）通过NADPH氧化酶4（NOX4）和一氧化氮依赖性机制促进血管生成和缺血诱导的新血管形成。
2. The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells [J] . Hongyun Tang, Yong Qin, Jianyong Li, BMC Biology . 2011,第1期

机译：在肿瘤坏死因子相关的凋亡诱导配体抵抗性白血病细胞中，超氧化物自由基的清除促进由新型细胞渗透性融合蛋白sTRAIL：FeSOD诱导的凋亡。
3. Evidence that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits angiogenesis by inducing vascular endothelial cell apoptosis. [J] . Chen PL, Easton AS Biochemical and Biophysical Research Communications . 2010,第1期

机译：肿瘤坏死因子相关凋亡诱导配体（TRAIL）通过诱导血管内皮细胞凋亡抑制血管生成的证据。
4. Effect of Molecular Size of PEGylated tumor necrosis factor factor-related apoptosis apoptosis-inducing ligand(TRAIL) : T The Biological Activity and he Stability [C] . Tae Hyung Kim, Su Young Chae, Seung Min Byun, Annual meeting exposition of the Controlled Release Society . 2009

机译：PEG化肿瘤坏死因子相关细胞凋亡诱导配体（TRAIL）分子大小的影响生物学活性和稳定性
5. Modulation of tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors in a human osteoclast model in vitro. [D] . McManus, Stephen. 2011

机译：在人类破骨细胞模型中调节肿瘤坏死因子相关的凋亡诱导配体（TRAIL）受体。
6. Tumor Necrosis Factor–Related Apoptosis‐Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia‐Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide–Dependent Mechanisms [O] . Belinda Ann Di Bartolo, Siân Peta Cartland, Leonel Prado‐Lourenco, 2015

机译：肿瘤坏死因子相关的凋亡诱导配体（TRAIL）通过NADPH氧化酶4（NOX4）和一氧化氮依赖性机制促进血管生成和局部缺血诱导的新血管形成。
7. Tumor Necrosis Factor - Related Apoptosis-Inducing Ligand (TRAIL) promotes angiogenesis and ischemia- induced neovascularization via NADPH Oxidase 4 (NOX4) and Nitric Oxide - dependent mechanisms [O] . Di Bartolo B, Cartland S, Prado-Lourenco L, 2015

机译：肿瘤坏死因子相关凋亡诱导配体（TRaIL）通过NaDpH氧化酶4（NOX4）和一氧化氮依赖性机制促进血管生成和缺血诱导的新生血管形成
8. Modulators of Response to Tumor Necrosis-Factor-Related Apoptosis Inducing Ligand (TRAIL) Therapy in Ovarian Cancer [R] . Behbakht, K. 2010

机译：肿瘤坏死因子相关凋亡诱导配体（TRaIL）治疗卵巢癌的调节因子

Tumor Necrosis Factor–Related Apoptosis‐Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia‐Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide–Dependent Mechanisms

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