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首页> 外文期刊>Journal of the Brazilian Chemical Society >Determination of protonation constants of some tetracycline antibiotics by potentiometry and lc methods in water and acetonitrile-water binary mixtures
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Determination of protonation constants of some tetracycline antibiotics by potentiometry and lc methods in water and acetonitrile-water binary mixtures

机译：电位法和液相色谱法测定水和乙腈-水二元混合物中某些四环素抗生素的质子化常数

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摘要

An accurate estimation of dissociation constants of tetracycline antibiotics in acetonitrile-water binary mixtures is very important for several separation techniques such as liquid chromatography and capillary electrophoresis that use these solvent mixtures. In this study, the pKa values of five tetracyclines (tetracycline, oxytetracycline, chlortetracycline, doxycycline and metacycline), have been determined in water and acetonitrile-water binary mixtures (10%, 20% and 30% (v/v)) by potentiometry and liquid chromatography (LC). The obtained results show a similar trend for the pKa1 values of five tetracycline antibiotics as they increase with increasing concentration of organic modifier, which allows a linear relationship between pKa1 values and mole fraction of acetonitrile to be obtained. The pKa values obtained in aqueous medium have been compared with the values predicted by the SPARC on-line pKa calculator.
机译：准确估算乙腈-水二元混合物中四环素类抗生素的解离常数对于使用这些溶剂混合物的几种分离技术（例如液相色谱和毛细管电泳）非常重要。在这项研究中，通过电位计测定了水和乙腈-水二元混合物（10％，20％和30％（v / v））中的五个四环素（四环素，土霉素，金霉素，多西环素和间环素）的pKa值和液相色谱（LC）。获得的结果显示出五种四环素类抗生素的pKa1值具有相似的趋势，因为它们随着有机改性剂浓度的增加而增加，这使得pKa1值与乙腈的摩尔分数之间具有线性关系。在水介质中获得的pKa值已与SPARC在线pKa计算器预测的值进行了比较。

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