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首页> 外文期刊>Journal of the Brazilian Chemical Society >Modulation of the catalytic activity of porphyrins by lipid-and surfactant-containing nanostructures
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Modulation of the catalytic activity of porphyrins by lipid-and surfactant-containing nanostructures

机译：含脂质和表面活性剂的纳米结构对卟啉催化活性的调节

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The structural factors modulating porphyrin activity encompass pyrrole and equatorial ligands, as well as the central metal and the number and structure of their axial ligands. Of equal importance is the microenvironment provided by apoproteins, solvents and membranes. Porphyrins are often used to construct supramolecular structures with different applications. The modulation of activity of the porphyrins has been frequently achieved by mimicking nature, i.e., by the provision of different microenvironments for these molecules. The association of porphyrins to surfactant- and lipid-containing nanostructures has changed the activity of these compounds to mimic different enzymes such as SOD, cytochrome P450, peroxidases and others. In determined conditions, the reactive forms of the porphyrins are high-valence states of oxo-metal-πcations and oxo-metal produced by the reaction with peroxides and peracids. The modulation of porphyrin activity by surfactant- and lipid-containing nanostructures has also been achieved for hemeproteins, as the lipid nanostructures affect the conformation of proteins.
机译：调节卟啉活性的结构因素包括吡咯和赤道配体，以及中心金属及其轴向配体的数量和结构。同样重要的是载脂蛋白，溶剂和膜提供的微环境。卟啉通常用于构建具有不同应用的超分子结构。卟啉活性的调节通常是通过模仿自然，即通过为这些分子提供不同的微环境来实现的。卟啉与含表面活性剂和脂质的纳米结构的结合改变了这些化合物模拟不同酶（例如SOD，细胞色素P450，过氧化物酶等）的活性。在确定的条件下，卟啉的反应形式是通过与过氧化物和过酸反应生成的高价态的金属羰基阳离子和金属羰基。血红蛋白还通过含表面活性剂和脂质的纳米结构调节了卟啉活性，因为脂质纳米结构影响蛋白质的构象。

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