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首页> 外文期刊>Journal of the Egyptian Women s Dermatologic Society >Metabolic syndrome in Egyptian patients with vitiligo: a casea??control study
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Metabolic syndrome in Egyptian patients with vitiligo: a casea??control study

机译：埃及白癜风患者代谢综合征的病例对照研究

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ed to systemic inflammatory disorders such as obesity and MS. Objective To clarify the association of vitiligo with chronic vascular and metabolic disorders that constitute MS. Patients and methods A casea??control study was carried out on 102 vitiligo patients and 89 age-matched and sex-matched healthy controls. MS and its individual components (abdominal obesity, hypertension, insulin resistance, and dyslipidemia) were compared between cases and controls. Results BMI, waist circumference (WC), and serum triglycerides (TGs) were significantly lower in the patient group than the control group, whereas diastolic blood pressure, serum high-density lipoprotein cholesterol, serum fasting insulin, and insulin resistance were significantly higher in the patient group than the control group. There were no significant differences between cases and controls regarding systolic blood pressure, fasting blood glucose, and number of patients having MS. Serum fasting insulin was significantly the highest in patients with acrofacial vitiligo compared with other types of vitiligo. Patients with MS had significantly higher mean age, disease duration, Vitiligo Area Scoring Index (disease severity), and insulin resistance compared with patients without MS. Age, serum TGs, body weight, BMI, WC, and insulin resistance showed significant positive correlations with Vitiligo Area Scoring Index (disease severity). Conclusion Vitiligo patients showed a better lipid profile, with higher levels of high-density lipoprotein cholesterol and lower TGs and WC values. In patients with vitiligo, increased insulin levels and insulin resistance may be related to other mechanisms than obesity, such as production of cytokines or autoimmune reaction to melanocytes. Further large-scale studies are needed to confirm these findings....
机译：会引起全身性炎症，例如肥胖症和MS。目的阐明白癜风与构成MS的慢性血管和代谢疾病的关系。患者和方法对102名白癜风患者和89名年龄匹配和性别匹配的健康对照者进行了casea ??对照研究。在病例和对照之间比较了MS及其个体成分（腹部肥胖，高血压，胰岛素抵抗和血脂异常）。结果患者组的BMI，腰围（WC）和血清甘油三酸酯（TGs）明显低于对照组，而舒张压，血清高密度脂蛋白胆固醇，血清空腹胰岛素和胰岛素抵抗明显高于对照组。患者组比对照组。病例和对照之间在收缩压，空腹血糖和MS患者数量方面无显着差异。与其他类型的白癜风相比，先天性白癜风患者的空腹胰岛素水平最高。与没有MS的患者相比，MS的患者的平均年龄，疾病持续时间，白癜风面积评分指数（疾病严重程度）和胰岛素抵抗明显更高。年龄，血清TG，体重，BMI，WC和胰岛素抵抗与白癜风面积评分指数（疾病严重程度）呈显着正相关。结论白癜风患者的血脂状况较好，高密度脂蛋白胆固醇水平较高，TGs和WC值较低。在患有白癜风的患者中，胰岛素水平升高和胰岛素抵抗可能与肥胖以外的其他机制有关，例如细胞因子的产生或对黑素细胞的自身免疫反应。需要进一步的大规模研究来证实这些发现。

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