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首页> 外文期刊>Journal of the International Association of Providers of AIDS Care. >Relationship of Vitamin D, HIV, HIV Treatment, and Lipid Levels in the Women’s Interagency HIV Study of HIV-Infected and Uninfected Women in the United States
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Relationship of Vitamin D, HIV, HIV Treatment, and Lipid Levels in the Women’s Interagency HIV Study of HIV-Infected and Uninfected Women in the United States

机译：在美国针对感染HIV和未感染HIV的女性的跨部门HIV研究中，维生素D，HIV，HIV治疗和血脂水平之间的关系

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Relationships between vitamin D, lipids, HIV infection, and HIV treatment (±antiretroviral therapy [ART]) were investigated with Women’s Interagency HIV Study data (n = 1758 middle-aged women) using multivariable regression. Sixty-three percent of women had vitamin D deficiency. Median 25-hydroxyvitamin D (25-OH vitamin D) was highest in HIV-infected + ART-treated women (17 ng/mL; P .001) and was the same in HIV-uninfected or HIV-infected women without ART (14 ng/mL). Vitamin D levels were lower if efavirenz (EFV) was included in ART (15 versus 19 ng/mL; P .001). The most common lipid abnormality was high triglycerides (≥200 mg/dL) in HIV-infected + ART-treated women (13% versus 7% of HIV-infected without ART and 5% of HIV-uninfected; P .001), with a positive relationship between 25-OH vitamin D and triglycerides (95% confidence interval 0.32-1.69; P .01). No relationships between 25-OH vitamin D and cholesterol were detected. Vitamin D deficiency is common irrespective of HIV status but influenced by HIV treatment. Similarly, vitamin D levels were positively related to triglycerides only in ART-treated HIV-infected women and unrelated to cholesterol.
机译：维生素D，脂质，HIV感染和HIV治疗（±抗逆转录病毒治疗[ART]）之间的关系使用多变量回归，通过妇女机构间HIV研究数据（n = 1758中年妇女）进行了调查。 63％的女性患有维生素D缺乏症。中位数25-羟基维生素D（25-OH维生素D）在HIV感染+ ART治疗的女性中最高（17 ng / mL; P <.001），在未感染ART或未感染HIV的女性中相同（ 14 ng / mL）。如果将依非韦伦（EFV）包括在抗逆转录病毒治疗中，维生素D的水平会降低（15 vs. 19 ng / mL; P <.001）。最常见的脂质异常是在HIV感染+ ART治疗的女性中高甘油三酸酯（≥200mg / dL）（13％比7％的未感染ART的HIV感染者和5％的HIV未感染者; P <.001），与25-羟基维生素D和甘油三酸酯呈正相关（95％置信区间0.32-1.69; P <0.01）。没有发现25-OH维生素D与胆固醇之间的关系。维生素D缺乏症是常见的，与HIV状况无关，但受HIV治疗的影响。同样，维生素D水平仅在接受抗逆转录病毒治疗的HIV感染妇女中与甘油三酸酯呈正相关，与胆固醇无关。

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