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首页> 外文期刊>Journal of the International Society of Sports Nutrition >Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial
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Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial

机译：急性可可黄酮摄入量对健康骑自行车者的运动诱发的氧化应激和一氧化氮的产生影响最小：一项随机对照试验

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BackgroundCocoa flavanols (CF) can stimulate vasodilation by improved nitric oxide (NO) synthesis and have antioxidant and anti-inflammatory capacities. This study aimed to examine whether acute CF intake can affect exercise-induced changes in antioxidant capacity, oxidative stress, inflammation and NO production, as well as exercise performance and recovery in well-trained cyclists . MethodsTwelve well-trained male cyclists (mean?±?SD age, VO2max: 30?±?3?years, 63.0?±?3.5?ml/kg/min) participated in this randomized, double-blind, cross over study. On 2 separate occasions, subjects performed two 30-min time trials 1.5 (TT1) and 3 (TT2) hours after CF (900?mg CF) or placebo (PL, 13?mg CF) intake, interposed by passive rest. Lactate, glucose, heartrate, rating of perceived exertion (RPE) and power output were measured during the TTs. Blood was drawn at baseline, before and after each TT and analyzed for epicatechin serum concentrations, trolox equivalent antioxidative capacity (TEAC), uric acid (UA), malonaldehyde (MDA), L-arginine/ADMA, citrulline, interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α plasma concentrations. Relative changes in blood markers and pacing strategy during TT were analysed by repeated measured ANOVA. TT performance was compared between PL and CF by paired t-test. ResultsEpicatechin concentrations were increased by CF intake. Exercise-induced increase in TEAC/UA was improved by CF intake (F(1)?=?5.57; p =?.038) (post-TT1: PL: 113.34?±?3.9%, CF: 117.64?±?3.96%, post-TT2: PL: 108.59?±?3.95%, CF: 123.72?±?7.4% to baseline), while exercise-induced increases in MDA,?IL-1 and IL-6 were not affected by CF intake. TNF-α was unaltered by exercise and by CF. Exercise-induced decreases in L-arginine/ADMA and increases in citrulline were not affected by CF intake. TT1 and TT2 performance and exercise-induced physiological changes were unaffected by CF intake. ConclusionAcute CF intake increased total antioxidant capacity in rest and during exercise, but did not affect exercise-induced lipid peroxidation, inflammation, nor NO production in healthy athletes. Acute CF intake did not improve TT performance and recovery. Trial registration ISRCTN32875 , 21-11-2016, retrospectively registered.
机译：背景可可黄烷醇（CF）可以通过改善一氧化氮（NO）的合成来刺激血管舒张，并具有抗氧化和抗炎的能力。这项研究旨在检查急性CF摄入量是否会影响运动引起的抗氧化能力，氧化应激，炎症和NO生成的变化，以及训练有素的自行车手的运动表现和恢复能力。方法：十二名训练有素的男性自行车手（平均年龄±SD岁，最大摄氧量：30±3岁3岁，63.0±3.5ml / kg / min）参加了这项随机，双盲，交叉研究。在2次不同的情况下，受试者在摄入CF（900？mg CF）或安慰剂（PL，13？mg CF）之后的1.5个小时（TT1）和3个小时（TT2）进行了两次30分钟的时间试验，并进行了被动休息。在TT期间测量乳酸，葡萄糖，心率，感知劳累等级（RPE）和功率输出。在每次TT之前和之后的基线抽取血液，并分析表儿茶素的血清浓度，trolox等效抗氧化能力（TEAC），尿酸（UA），丙二醛（MDA），L-精氨酸/ ADMA，瓜氨酸，白介素（IL） 1，IL-6和肿瘤坏死因子（TNF）-α的血浆浓度。通过重复测量的ANOVA分析TT期间血液标志物和起搏策略的相对变化。通过配对t检验比较PL和CF之间的TT性能。结果摄入CF可以增加表儿茶素的浓度。 CF摄入可改善运动引起的TEAC / UA升高（F（1）？=？5.57; p = ?. 038）（TT1后：PL：113.34？±？3.9％，CF：117.64？±？3.96 TT2后的百分比：相对于基线，PL：108.59±3.95％，CF：123.72±7.4％），而运动引起的MDA升高，IL-1和IL-6不受CF摄入量的影响。运动和CF不会改变TNF-α。运动引起的L-精氨酸/ ADMA减少和瓜氨酸增加不受CF摄入量的影响。摄入CF不会影响TT1和TT2的表现以及运动引起的生理变化。结论急性CF摄入增加了休息和运动过程中的总抗氧化能力，但并未影响健康运动员运动引起的脂质过氧化，炎症或NO生成。急性CF摄入量并未改善TT性能和恢复能力。试用注册ISRCTN32875，2016年11月11日，追溯注册。

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