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首页> 外文期刊>Journal of the International Association of Providers of AIDS Care. >Incidence and Risk Factors of Nasal Carriage of Staphylococcus aureus in HIV-Infected Individuals in Comparison to HIV-Uninfected Individuals: A Case–Control Study
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Incidence and Risk Factors of Nasal Carriage of Staphylococcus aureus in HIV-Infected Individuals in Comparison to HIV-Uninfected Individuals: A Case–Control Study

机译：与未感染艾滋病毒的个体相比，在HIV感染个体中金黄色葡萄球菌鼻腔运输的发生率和危险因素

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The study was conducted to evaluate the prevalence of nasal colonization of Staphylococcus aureus in individuals with HIV infection attending the Integrated Counselling and Testing Centre in a teaching hospital and compare the prevalence with HIV-uninfected individuals. A case–control study was conducted among newly diagnosed HIV-infected individuals and an equal number of age-group and sex-matched HIV-uninfected individuals, and nasal swabs were collected from both the samples. Sociodemographic and clinical data were collected through individual interviews. Ethical aspects were respected. A total of 100 individuals participated in the study, and 22 (44%) of the 50 HIV-infected cases were colonized by S aureus, including 19 (86.4%) methicillin-sensitive S aureus (MSSA) and 3 (13.6%) methicillin-resistant S aureus (MRSA). Only 12 (24%) strains were isolated from 50 HIV-uninfected individuals, with 11 being MSSA and 1 being MRSA. This difference in the isolation rate was statistically significant (P = .035). The 2 most commonly encountered risk factors in both the groups appeared to be history of tuberculosis and history of surgical procedures but none being statistically significant (P = .093 and P = .996).?All the strains of S aureus were sensitive to mupirocin. The study concluded that HIV-infected individuals are at a higher risk of carriage as compared to HIV-uninfected individuals. By eliminating carriage in immunocompromised individuals, infections due to S aureus can also be minimized.
机译：这项研究旨在评估在教学医院的综合咨询和测试中心接受艾滋病毒感染的人中金黄色葡萄球菌鼻部定植的患病率，并将其与未感染艾滋病毒的人进行比较。在新诊断出的HIV感染者以及年龄，性别匹配的未感染HIV者中进行了病例对照研究，并从两个样本中收集了鼻拭子。通过个人访谈收集了社会人口统计学和临床​​数据。在道德方面受到尊重。总共有100个人参加了该研究，在50个HIV感染病例中有22个（44％）被金黄色葡萄球菌定殖，包括19个（86.4％）甲氧西林敏感性金黄色葡萄球菌（MSSA）和3个（13.6％）甲氧西林耐药金黄色葡萄球菌（MRSA）。从50个未感染HIV的个体中仅分离出12个菌株（24％），其中11个为MSSA，1个为MRSA。隔离率的差异具有统计学意义（P = .035）。两组中最常遇到的两个危险因素似乎是结核病史和外科手术史，但均无统计学意义（P = .093和P = .996）。所有金黄色葡萄球菌菌株对莫匹罗星敏感。该研究得出的结论是，与未感染艾滋病毒的人相比，感染了艾滋病毒的人有更高的携带风险。通过消除免疫力低下的个体中的携带，也可以将因金黄色葡萄球菌引起的感染降至最低。

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