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首页> 外文期刊>Journal of the International Society of Sports Nutrition >Minimal dose of milk protein concentrate to enhance the anabolic signalling response to a single bout of resistance exercise; a randomised controlled trial
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Minimal dose of milk protein concentrate to enhance the anabolic signalling response to a single bout of resistance exercise; a randomised controlled trial

机译：最小剂量的浓缩乳蛋白，以增强对单次抵抗运动的合成代谢信号响应;随机对照试验

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BackgroundResistance training is a potent stimulus to induce muscle hypertrophy. Supplemental protein intake is known to enhance gains in muscle mass through activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway, which initiates protein translation. While the optimal dose of high quality protein to promote post exercise anabolism in young or older men has been investigated, little is known about the minimum doses of protein required to potentiate the resistance exercise activation of anabolic signalling in middle aged men. MethodsTwenty healthy men (46.3?±?5.7?years, BMI: 23.9?±?6.6?kg/m2) completed a single bout of unilateral resistance exercise consisting of 4 sets of leg extension and press at 80% of 1 repetition maximum. Participants were randomised to consume either formulated milk product containing 9?g milk protein (FMP) or an isoenergetic carbohydrate placebo (CHO) immediately post exercise, in a double blind fashion. A single muscle biopsy was collected at pre-exercise baseline and then bilateral biopsies were collected 90 and 240?min after beverage consumption. ResultsP70S6KThr389 phosphorylation was increased with exercise irrespective of group, P70S6KThr421/Ser424 was increased with exercise only in the FMP group at 240?min. Likewise, rpS6 Ser235/236 phosphorylation was increased with exercise irrespective of group, rpS6 Ser240/244 increased to a greater extent following exercise in the FMP group. mRNA expression of the amino acid transporter, LAT1/ SLC7A5 increased with both exercise and beverage consumption irrespective of group. PAT1/ SLC36A1 , CAT1/ SLC7A1 and SNAT2/ SLC38A2 mRNA increased only after exercise regardless of group. ConclusionsNine grams of milk protein is sufficient to augment some measures of downstream mTORC1 signalling after resistance exercise but does not potentiate exercise induced increases in amino acid transporter expression. Formulated products containing nine grams of milk protein would be expected stimulate muscle anabolism after resistance exercise. Trial registrationNew Zealand Clinical Trials Registry ACTRN12615001375549 . Registered: 17 December, 2015.
机译：背景技术阻力训练是诱发肌肉肥大的有效刺激。已知补充蛋白质的摄入可通过激活雷帕霉素复合物1（mTORC1）途径的哺乳动物靶标来激活肌肉质量，从而启动蛋白质翻译。尽管已经研究了在年轻或老年男性中促进运动后合成代谢的最佳剂量的最佳蛋白质，但对于增强中年男性合成代谢信号的抗性锻炼激活所需的最小蛋白质最小剂量知之甚少。方法二十名健康男性（46.3？±？5.7？岁，BMI：23.9？±？6.6？kg / m 2 ）完成了单侧单侧抵抗运动，包括4组伸腿并按最多1次重复的80％。参与者随机分组，以双盲方式食用运动后立即食用的含9？g乳蛋白（FMP）的配方乳制品或同能碳水化合物安慰剂（CHO）。在运动前的基线进行一次肌肉活检，然后在饮酒90分钟和240分钟后进行双侧活检。结果不论运动与否，P70S6K Thr389 的磷酸化均增加，而仅在FMP组运动240min时，P70S6K Thr421 / Ser424 的升高仅随运动而增加。同样，运动无关的rpS6 Ser235 / 236 磷酸化水平升高，而FMP组运动后rpS6 Ser240 / 244 升高程度更大。氨基酸转运蛋白LAT1 / SLC7A5的mRNA表达随运动和饮料消费而增加，与组无关。 PAT1 / SLC36A1，CAT1 / SLC7A1和SNAT2 / SLC38A2 mRNA仅在运动后增加，而与组无关。结论9克牛奶蛋白足以增强抵抗运动后下游mTORC1信号传导的某些指标，但不能增强运动引起的氨基酸转运蛋白表达的增加。抵抗运动后，预期含有9克牛奶蛋白的配方产品将刺激肌肉合成代谢。试用注册新西兰临床试验注册中心ACTRN12615001375549。注册于：2015年12月17日。

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