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首页> 外文期刊>Journal of Veterinary Advances >Evaluation of Serial Measurements of Selected Biomarkers in Serum and Peritoneal Fluid for the Diagnosis of Intestinal Ischemia in Donkeys: An Experimental Study
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Evaluation of Serial Measurements of Selected Biomarkers in Serum and Peritoneal Fluid for the Diagnosis of Intestinal Ischemia in Donkeys: An Experimental Study

机译：血清和腹膜液中所选生物标志物系列测定对驴肠缺血的诊断评价：一项实验研究

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Up to now, there has been limited evidence relating to the early diagnostic approach of colic in equine patients. The purpose of this study was to evaluate serial measurements of selected biomarkers in both serum and peritoneal fluid (PF) in donkeys underwent experimental intestinal obstruction owing to early detection of intestinal. For this purpose, four apparently healthy male donkeys (Equus asinus) were randomly purchased based on their health condition and were thoroughly examined to rule out concurrent or even previous ailments. Following a standard pre-surgical and surgical precautions, these animals were subjected to intestinal ischemia via complete ligation of ileum and its mesentery. The animals were clinically and ultrasonographically monitored for 72 hours. Paired samples of blood and PF were collected from each animal before surgery (T0) and following surgical intervention at the following time points: T12, T24, T48 and T72 to measure the respective levels of L-lactate, nitric oxide (NO), total alkaline phosphatase (TAP), lipase and cardiac troponin I (CTnI). The results herein demonstrated that the pattern of both PF and blood lactate were significantly higher at T72 than those at other time points (P< 0.05). Serum values of NO, AP, lipase and CTnI, despite being not significantly changed among the different time points, their respective levels in the PF were altered significantly when compared with their levels in serum (P<0.05). The obtained findings indicated that PF can be used as a potential diagnostic indicator for the early detection of intestinal ischemia in donkeys.
机译：迄今为止，有关马患者绞痛的早期诊断方法的证据有限。这项研究的目的是评估由于早期发现肠道而在经历实验性肠梗阻的驴中血清和腹膜液（PF）中所选生物标志物的系列测量结果。为此，根据健康状况随机购买了四只看上去健康的雄性驴（马属驴），并对其进行了彻底检查以排除并发疾病甚至以前的疾病。遵循标准的术前和手术预防措施，通过完全结扎回肠及其肠系膜，对这些动物进行肠缺血。对动物进行临床和超声检查72小时。在手术前（T0）和以下时间点进行手术干预后，从每只动物中采集配对的血液和PF样品：T12，T24，T48和T72，以测量各自的L-乳酸，一氧化氮（NO），总水平碱性磷酸酶（TAP），脂肪酶和心肌肌钙蛋白I（CTnI）。本文的结果表明，PF和血液乳酸的模式在T72时均显着高于其他时间点（P <0.05）。血清中NO，AP，脂肪酶和CTnI的值虽然在不同时间点之间没有显着变化，但与血清中的水平相比，其各自在PF中的水平却发生了显着变化（P <0.05）。获得的发现表明，PF可以用作早期检测驴肠缺血的潜在诊断指标。

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