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首页> 外文期刊>Journal of Therapeutic Ultrasound >A convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided high-intensity focused ultrasound systems with phased array transducers
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A convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided high-intensity focused ultrasound systems with phased array transducers

机译：一种用于相控阵换能器的磁共振引导高强度聚焦超声系统的便捷，可靠，快速的声压场测量方法

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Background With the expanding applications of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU), there is an urgent need for a convenient, reliable, and fast acoustic pressure field measurement method to aid treatment protocol design, ensure consistent and safe operation of the transducer, and facilitate regulatory approval of new techniques. Herein, we report a method for acoustic pressure field characterization of MR-HIFU systems with multi-element phased array transducers. This method integrates fiber-optic hydrophone measurements and electronic steering of the ultrasound beam with MRI-assisted HIFU focus alignment to the fiber tip. Methods A clinical MR-HIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) was used to assess the proposed method. A fiber-optic hydrophone was submerged in a degassed water bath, and the fiber tip location was traced using MRI. Subsequently, the nominal transducer focal point indicated on the MR-HIFU therapy planning software was positioned at the fiber tip, and the HIFU focus was electronically steered around the fiber tip within a 3D volume for 3D pressure field mapping, eliminating the need for an additional, expensive, and MRI-compatible 3D positioning stage. The peak positive and negative pressures were measured at the focus and validated using a standard hydrophone measurement setup outside the MRI magnet room. Results We found that the initial MRI-assisted HIFU focus alignment had an average offset of 2.23?±?1.33?mm from the fiber tip as identified by the 3D pressure field mapping. MRI guidance and electronic beam steering allowed 3D focus localization within ~?1?h, i.e., faster than the typical time required using the standard laboratory setup (~?3–4?h). Acoustic pressures measured using the proposed method were not significantly different from those obtained with the standard laboratory hydrophone measurements. Conclusions In conclusion, our method offers a convenient, reliable, and fast acoustic pressure field characterization tool for MR-HIFU systems with phased array transducers.
机译：背景技术随着磁共振引导的高强度聚焦超声（MR-HIFU）的广泛应用，迫切需要一种方便，可靠和快速的声压场测量方法，以帮助治疗方案设计，确保一致和安全的操作。换能器，并促进新技术的监管批准。在这里，我们报告了一种具有多元素相控阵换能器的MR-HIFU系统声压场表征方法。该方法将光纤水听器测量和超声束的电子控制与MRI辅助的HIFU聚焦对准光纤尖端集成在一起。方法使用临床MR-HIFU系统（加拿大密西沙加Profound Medical Inc.的Sonalleve V2）评估该方法。将光纤水听器浸没在脱气的水浴中，并使用MRI跟踪光纤尖端的位置。随后，将MR-HIFU治疗计划软件上指示的标称换能器焦点定位在光纤尖端，然后将HIFU聚焦电子控制在3D体积内的光纤尖端周围，以进行3D压力场映射，从而无需额外的，昂贵且与MRI兼容的3D定位平台。在焦点处测量峰值正压和负压，并使用MRI磁体室外部的标准水听器测量设置进行验证。结果我们发现，由MRI辅助的HIFU初始聚焦对准与3D压力场作图所确定的平均距光纤尖端的偏移为2.23？±？1.33？mm。 MRI引导和电子束控制使3D焦点定位在大约1小时内，即比使用标准实验室设置所需的典型时间（大约3至4小时）要快。使用建议的方法测量的声压与标准实验室水听器测量获得的声压没有显着差异。结论总之，我们的方法为相控阵换能器的MR-HIFU系统提供了方便，可靠和快速的声压场表征工具。

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