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首页> 外文期刊>Journal of Tissue Engineering >In Vitro Biocompatibility and Mechanical Performance of Titanium Doped High Calcium Oxide Metaphosphate-Based Glasses
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In Vitro Biocompatibility and Mechanical Performance of Titanium Doped High Calcium Oxide Metaphosphate-Based Glasses

机译：钛掺杂高氧化钙偏磷酸盐基玻璃的体外生物相容性和力学性能

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This study challenged to produce phosphate-based glasses (PBG) for the treatment of osseous defects. The glasses contained, among other components, 40 mol% CaO and 1–5 mol% TiO2. The mechanical performance and in vitro biocompatibility using both human osteosarcoma and primary osteoblasts were carried out. Incorporation of TiO2 into PBG had no significant effect on strength and modulus. These glasses encouraged attachment and maintained high viability of osteosarcoma cells similar to the positive control surface. Cells grown directly (on glasses) or indirectly (in the presence of glass extracts) showed similar proliferation pattern to the positive control cells with no significant effect of TiO2 detected. Increasing TiO2 content, however, has a profound effect on cytoskeleton organization and spreading and maturation of primary osteoblasts. It is believed that TiO2 might have acted as a chemical cue-modulating cells response, and hence the substrates supported maturation/mineralization of the primary osteoblasts.
机译：这项研究对生产用于治疗骨质缺损的磷酸盐基玻璃（PBG）提出了挑战。除其他成分外，玻璃还包含40 mol％的CaO和1-5 mol％的TiO2。进行了使用人骨肉瘤和原代成骨细胞的机械性能和体外生物相容性。在PBG中掺入TiO2对强度和模量没有明显影响。这些眼镜鼓励附着并保持与阳性对照表面相似的骨肉瘤细胞的高生存能力。直接（在玻璃上）或间接（在玻璃提取物存在下）生长的细胞显示出与阳性对照细胞相似的增殖模式，但未检测到TiO2的显着影响。然而，增加TiO2的含量对原代成骨细胞的细胞骨架组织，扩散和成熟具有深远的影响。据信，TiO 2可能起了化学提示调节细胞反应的作用，因此底物支持原代成骨细胞的成熟/矿化。

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